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MTHFRC677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese
- Source :
- Acta Neurologica Scandinavica. 130:e30-e34
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Background Genetic variability of methylenetetrahydrofolate reductase (MTHFR) may be associated with Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. Our study aimed to investigate whether MTHFR C677T variation was linked to PD risk in a Han Chinese population from mainland China. Methods To investigate the association with the risk of PD, we analyzed the single-nucleotide polymorphism C677T in MTHFR gene using a case–control methodology. A total of 1482 subjects included 765 patients with idiopathic PD, and 717 age- and sex-matched controls were recruited in this study. Results The T allele of MTHFR C677T was associated with a decreased risk of PD (OR = 0.80, 95% CI: 0.688–0.926, P = 0.003). Patients with CT + TT genotypes have a decreased risk of PD compared with those with CC genotypes (OR = 0.66, 95%CI: 0.532–0.813, P = 0.000). CT + TT subjects cannot be differentiated from CC subjects based on their clinical features. Conclusion We showed that the C677T polymorphism in MTHFR gene was associated with decreased PD susceptibility in a Han Chinese population from mainland China. Efforts to fully elucidate the pathophysiologic role of the variant in PD should be necessary.
- Subjects :
- Adult
Male
Risk
China
medicine.medical_specialty
Genotype
Population
Disease
Polymorphism, Single Nucleotide
Gastroenterology
Asian People
Polymorphism (computer science)
Internal medicine
Humans
Medicine
SNP
Genetic Predisposition to Disease
Genetic variability
Allele
education
Alleles
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Aged, 80 and over
Genetics
education.field_of_study
biology
business.industry
Parkinson Disease
General Medicine
Middle Aged
digestive system diseases
Neurology
Case-Control Studies
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Methylenetetrahydrofolate reductase
biology.protein
Female
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 00016314
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Acta Neurologica Scandinavica
- Accession number :
- edsair.doi.dedup.....85e8c157507021ec9104368f3c3400f3