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No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
- Source :
- Korean Journal of Pathology
- Publication Year :
- 2013
- Publisher :
- The Korean Society of Pathologists and The Korean Society for Cytopathology, 2013.
-
Abstract
- Simian virus 40 (SV40) is a polyomavirus that originates from the rhesus macaque and was discovered in 1960 as a contaminant of human polio vaccines produced in monkey cells.1 Recently, there has been considerable interest in the identification of SV40 in human tumors, including malignant mesothelioma (MM) and other rare tumors such as osteosarcoma, ependymoma, and choroid plexus tumors.2-6 Subsequently, it has been found that SV40 may play an important role in the etiology of these tumors.2-6 However, SV40 was not detected in malignant lymphomas in Korean patients.7 Oncogenesis driven by SV40 is mediated by the large tumor antigen (T-Ag) oncoprotein, which is capable of transforming different types of cells in the absence of other viral genes.8,9 T-Ag induces DNA synthesis in host cells and prolongs the onset of the S-phase through the inhibition of tumor suppressor proteins p53 and Rb.8 MM is a rare and extremely aggressive neoplasm that arises from the serosal surfaces of pleural, peritoneal, and pericardial cavities and is very likely associated with amphibole asbestos exposure.10,11 In recent years, the incidence of MM has been gradually increasing in concert with industrial development and increased exposure to asbestos.12 However, only a small number of people who have been exposed to asbestos during their lifetime will develop MM.11 This suggests that SV40 may act as an independent carcinogenic agent or as a cofactor of asbestos to augment the risk of MM.13 Studies investigating the relation of SV40 to MM have been inconsistent and differ by geographical location.6 The incidence of MM varies according to geographic location, and the highest incidence rates are reported from Australia, Belgium, and Great Britain.14 In Korea, the incidence of MM is very low compared with other developed countries, with only about one case per million in the last decade.14,15 However, the incidence is recently increasing. Korea has a higher proportion of females (33.8%) among MM cases compared with other nations such as Canada (15.4%) or Italy (27.6%), and most of the patients are diagnosed when they are in their 50s, which is younger compared to cases in other countries.15 Although the majority of MM patients have had occupational (36.8%) and/or environmental (20.4%) asbestos exposure, the remaining patients (42.8%) had no known asbestos exposure.15 The role of SV40 in the oncogenesis of MM following asbestos exposure has not yet been studied in a Korean population. The purpose of this study is to identify SV40 DNA and protein in tissues extracted from MM from a Korean population using quantitative polymerase chain reaction (PCR) and immunohistochemical staining.
- Subjects :
- Ependymoma
Mesothelioma
Pathology
medicine.medical_specialty
business.industry
Incidence (epidemiology)
viruses
Simian virus 40
medicine.disease
medicine.disease_cause
Immunohistochemistry
Asbestos
Pathology and Forensic Medicine
Polymerase chain reaction
medicine
Osteosarcoma
Neoplasm
Original Article
Carcinogenesis
business
Carcinogen
Subjects
Details
- Language :
- English
- ISSN :
- 20928920 and 17381843
- Volume :
- 47
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Korean Journal of Pathology
- Accession number :
- edsair.doi.dedup.....860d4aace6d378b90ff83de49f369d34