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Oops! Resolving social dilemmas in frontotemporal dementia
- Source :
- Journal of neurology, neurosurgery, and psychiatry. 78(5)
- Publication Year :
- 2006
-
Abstract
- Objectives: Our social cognition model posits that social knowledge and executive resources guide interpersonal decision making. We investigated this model by examining the resolution of standardised social dilemmas in patients with a social and executive disorder (SOC/EXEC) caused by frontotemporal dementia (FTD). Methods: Patients with SOC/EXEC (n = 12) and those with progressive aphasia (APH, n = 14) completed measures requiring resolution of social dilemmas (Guilford’s Cartoon Predictions Test), social cognition (theory of mind false belief vignettes and a behavioural rating measure of empathy) and executive measures of cognitive flexibility (Visual Verbal Test). Regression analysis related judgments of social dilemmas to cortical volume using voxel based morphometry of high resolution structural MRI. Results: Patients with SOC/EXEC were impaired in judgments of social dilemmas as well as theory of mind, self-awareness of empathy and cognitive flexibility. Patients with APH were much less impaired in the social and cognitive measures. There were strong correlations among social dilemma, theory of mind and mental flexibility measures in patients with SOC/EXEC, and stepwise regression showed that mental flexibility was most predictive of social dilemma judgments. Social dilemma impairments in the SOC/EXEC sample correlated with cortical atrophy in the orbital frontal, superior temporal, visual association and posterior cingulate regions of the right hemisphere. Conclusions: Deficits in patients with SOC/EXEC in resolving social dilemmas are related to depleted executive resources and social knowledge that appear to arise from disease that interrupts a right frontal–temporal neural network crucial for mediating social cognition.
- Subjects :
- Paper
Male
media_common.quotation_subject
Decision Making
Empathy
Models, Psychological
behavioral disciplines and activities
Developmental psychology
Social cognition
Aphasia
Theory of mind
mental disorders
medicine
Humans
Interpersonal Relations
Social Behavior
media_common
Aged
Cognitive flexibility
nutritional and metabolic diseases
Brain
Cognition
Social dilemma
medicine.disease
Magnetic Resonance Imaging
humanities
nervous system diseases
Psychiatry and Mental health
Editorial Commentary
Regression Analysis
Surgery
Dementia
Female
Neurology (clinical)
medicine.symptom
Psychology
Cognition Disorders
Cognitive psychology
Frontotemporal dementia
Subjects
Details
- ISSN :
- 1468330X
- Volume :
- 78
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Accession number :
- edsair.doi.dedup.....861729ca3ad8c5b96d39d45e0751efda