Back to Search Start Over

Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study

Authors :
Bert Bravenboer
Hanneke J.B.H. Beijers
Casper G. Schalkwijk
Ronald M.A. Henry
Jacqueline M. Dekker
Isabel Ferreira
Giel Nijpels
Coen D.A. Stehouwer
Clinical sciences
RS: CAPHRI School for Public Health and Primary Care
MUMC+: KIO Kemta (9)
RS: CAPHRI - Clinical epidemiology
Interne Geneeskunde
Epidemiologie
RS: CARIM - R3 - Vascular biology
Epidemiology and Data Science
General practice
EMGO - Lifestyle, overweight and diabetes
Source :
Beijers, H J B H, Ferreira, I, Bravenboer, B, Henry, R M A, Schalkwijk, C G, Dekker, J M, Nijpels, G & Stehouwer, C D A 2014, ' Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study ', Atherosclerosis, vol. 233, no. 1, pp. 310-318 . https://doi.org/10.1016/j.atherosclerosis.2013.12.002, Atherosclerosis, 233(1), 310-318. Elsevier Ireland Ltd
Publication Year :
2014

Abstract

Objective: To investigate whether an adverse body composition is associated with endothelial dysfunction (ED) and the extent to which any such association could be explained by low-grade inflammation (LGI) and/or insulin resistance (HOMA2-IR). Methods: We studied 475 individuals from the Hoorn Study [mean (range) age, 68.9 (60-87) years, 245 women). Body composition was assessed by whole body dual-energy absorptiometry. Endothelial dysfunction was measured functionally, by flow-mediated dilation (FMD) and by circulating biomarkers. Associations were examined with multiple linear regression models and mediation analyses according to the ab product of coefficients method. Results: After adjustment for age, sex, glucose metabolism status, prior cardiovascular disease and lifestyle factors, total and central fat mass were positively associated with the ED score [beta = 0.16 (95% CI 0.04-0.29) and b 0.18 (0.05-0.31), respectively] and inversely, although not statistically significantly, with FMD. Peripheral fat mass was not associated with the ED score or FMD. There was a significant favourable association between peripheral lean mass and FMD [beta = 0.13 (0.00-0.26)], but not with the ED score. The association between total and central fat mass and the ED score was, to a great extent, mediated by LGI and HOMA2-IR. In contrast, LGI or HOMA2-IR did not mediate the association between peripheral lean mass and FMD. Conclusion: Higher levels of central, but not peripheral fat mass were adversely associated with ED, which was attributable to body composition-related LGI and insulin resistance. In contrast, peripheral lean mass was beneficially associated with ED, but this seemed to be unrelated to LGI or insulin resistance. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Details

ISSN :
00219150
Volume :
233
Issue :
1
Database :
OpenAIRE
Journal :
Atherosclerosis
Accession number :
edsair.doi.dedup.....861f67a63f248f237aebe7858dc7cd5e
Full Text :
https://doi.org/10.1016/j.atherosclerosis.2013.12.002