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Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study
- Source :
- Beijers, H J B H, Ferreira, I, Bravenboer, B, Henry, R M A, Schalkwijk, C G, Dekker, J M, Nijpels, G & Stehouwer, C D A 2014, ' Higher central fat mass and lower peripheral lean mass are independent determinants of endothelial dysfunction in the elderly: The Hoorn study ', Atherosclerosis, vol. 233, no. 1, pp. 310-318 . https://doi.org/10.1016/j.atherosclerosis.2013.12.002, Atherosclerosis, 233(1), 310-318. Elsevier Ireland Ltd
- Publication Year :
- 2014
-
Abstract
- Objective: To investigate whether an adverse body composition is associated with endothelial dysfunction (ED) and the extent to which any such association could be explained by low-grade inflammation (LGI) and/or insulin resistance (HOMA2-IR). Methods: We studied 475 individuals from the Hoorn Study [mean (range) age, 68.9 (60-87) years, 245 women). Body composition was assessed by whole body dual-energy absorptiometry. Endothelial dysfunction was measured functionally, by flow-mediated dilation (FMD) and by circulating biomarkers. Associations were examined with multiple linear regression models and mediation analyses according to the ab product of coefficients method. Results: After adjustment for age, sex, glucose metabolism status, prior cardiovascular disease and lifestyle factors, total and central fat mass were positively associated with the ED score [beta = 0.16 (95% CI 0.04-0.29) and b 0.18 (0.05-0.31), respectively] and inversely, although not statistically significantly, with FMD. Peripheral fat mass was not associated with the ED score or FMD. There was a significant favourable association between peripheral lean mass and FMD [beta = 0.13 (0.00-0.26)], but not with the ED score. The association between total and central fat mass and the ED score was, to a great extent, mediated by LGI and HOMA2-IR. In contrast, LGI or HOMA2-IR did not mediate the association between peripheral lean mass and FMD. Conclusion: Higher levels of central, but not peripheral fat mass were adversely associated with ED, which was attributable to body composition-related LGI and insulin resistance. In contrast, peripheral lean mass was beneficially associated with ED, but this seemed to be unrelated to LGI or insulin resistance. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- Subjects :
- Male
medicine.medical_specialty
Sarcopenia
BODY-COMPOSITION
Epidemiology
WEIGHT-LOSS
Dual-energy absorptiometry
elderly
endothelial dysfunction
Absorptiometry, Photon
Insulin resistance
PHENOTYPIC HETEROGENEITY
Weight loss
POSTLOAD GLUCOSE
medicine.artery
Internal medicine
BRACHIAL-ARTERY
Humans
Medicine
Endothelium
Endothelial dysfunction
Brachial artery
CARDIOVASCULAR EVENTS
Aged
Inflammation
business.industry
biomarkers
fat mass
Middle Aged
medicine.disease
Obesity
Vasodilation
Flow-mediated dilation
Endocrinology
Adipose Tissue
Regional Blood Flow
OBESITY
Arterial stiffness
Lean body mass
DEPENDENT VASODILATION
Body Composition
Female
Insulin Resistance
medicine.symptom
Cardiology and Cardiovascular Medicine
business
ARTERIAL STIFFNESS
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 233
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....861f67a63f248f237aebe7858dc7cd5e
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2013.12.002