Back to Search
Start Over
Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease
- Source :
- McGrattan, A M, McGuinness, B, McKinley, M C, Kee, F, Passmore, P, Woodside, J V & McEvoy, C T 2019, ' Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease ', Current Nutrition Reports, vol. 8, pp. 53–65 . https://doi.org/10.1007/s13668-019-0271-4, Current Nutrition Reports
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Purpose of ReviewNutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer’s disease (AD) and progression of neurodegeneration. Here, we review the evidence for healthy dietary patterns and age-related cognition and discuss potential neuroinflammatory actions of diet on cognitive function.Recent FindingsAnti-inflammatory dietary patterns such as the Mediterranean diet (MD) and dietary approaches to stop hypertension (DASH) may be neuroprotective. Several dietary components consumed in the MD and DASH (omega-3 fatty acids, antioxidants and polyphenols) can inhibit neuroinflammation associated with AD. Anti-inflammatory diets may also attenuate neuroinflammation via indirect immune pathways from the gut microbiome and systemic circulation.SummaryDiet may influence cognitive ageing via several inflammatory pathways. However, data from human studies are lacking and the exact mechanisms linking diet to cognitive function remain elusive. Further dietary intervention studies are required to investigate diet-associated neurological change from the earliest through to latest stages of cognitive decline. Furthermore, incorporation of neuroimaging measures in intervention studies would advance current understanding of the mechanistic effects of dietary modification on neuroinflammation in the ageing brain.
- Subjects :
- 0301 basic medicine
Disease
Diet, Mediterranean
Antioxidants
Pathogenesis
Cognition
0302 clinical medicine
Mechanisms
Dietary patterns
2. Zero hunger
Nutrition and Dietetics
Nutrition and Aging (Y Gu, Section Editor)
Cognitive ageing
Neurodegeneration
Brain
3. Good health
Elder Nutritional Physiological Phenomena
Cognitive function
medicine.symptom
Alzheimer’s disease
Pro-inflammatory diets
Dietary Approaches To Stop Hypertension
Nutritional Status
030209 endocrinology & metabolism
Inflammation
Clinical nutrition
Cognitive aging
03 medical and health sciences
Immune system
SDG 3 - Good Health and Well-being
Alzheimer Disease
Diabetes mellitus
Fatty Acids, Omega-3
medicine
Humans
Cognitive Dysfunction
Pathways
030109 nutrition & dietetics
business.industry
Public Health, Environmental and Occupational Health
Dietary approaches to stop hypertension (DASH)
Polyphenols
Nutrients
Mediterranean diet (MD)
medicine.disease
Gastrointestinal Microbiome
Diet
Cognitive Aging
Cognition Disorders
business
Neuroscience
Diet Therapy
Food Science
Subjects
Details
- ISSN :
- 21613311
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Current Nutrition Reports
- Accession number :
- edsair.doi.dedup.....86270d88cda10bd19a10b15010d695a2