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Association between vitamin D deficiency and serum Homocysteine levels and its relationship with coronary artery disease
- Source :
- Journal of Thrombosis and Thrombolysis
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Homocysteine (Hcy) elevation and vitamin D deficiency have emerged as potential markers of coronary artery disease (CAD). However, even tough hypovitaminosis D has been suggested to interfere with Hcy catabolism, no study has so far addressed the interaction of vitamin D and Hcy and their impact on CAD, that was the aim of present study. A cohort of consecutive patients undergoing coronary angiography in a single center were included and analyzed within the year 2019. Significant CAD was defined as at least 1 vessel stenosis > 50%, while severe CAD as left main and/or three-vessel disease. Hcy and vitamin D levels were assesssed at admission. We included 3150 patients undergoing coronary angiography at our centre, who were divided according to the quartiles values of vitamin D. Patients with lower levels of Vitamin D displayed a higher cardiovascular risk profile and a higher prevalence of CAD. We observed an inverse linear relationship between lower levels of vitamin D and higher Hcy (r = − 0.092, p
- Subjects :
- medicine.medical_specialty
Hyperhomocysteinemia
Homocysteine
Coronary angiography
Coronary Artery Disease
030204 cardiovascular system & hematology
Gastroenterology
vitamin D deficiency
Article
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
030212 general & internal medicine
Vitamin D
Coronary atherosclerosis
business.industry
Hematology
medicine.disease
Vitamin D Deficiency
Quartile
chemistry
Cohort
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 1573742X and 09295305
- Database :
- OpenAIRE
- Journal :
- Journal of Thrombosis and Thrombolysis
- Accession number :
- edsair.doi.dedup.....862c1398d309906a8d09e9a812d3e8b0