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Effect of beraprost on pulmonary hypertension due to left ventricular systolic dysfunction
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Beraprost is used to treat peripheral chronic arterial occlusive disease. However, the efficacy and safety of beraprost in patients with pulmonary hypertension (PH) due to left ventricular systolic dysfunction (PH-HFrEF) remains unknown. The primary objective of this study was to determine the effects of beraprost on PH-HFrEF. We prospectively recruited patients with PH-HFrEF as determined by echocardiography and right cardiac catheterization. Beraprost sodium was given orally (1 μg/kg/d) added to the usual treatment, and patients were evaluated at 1-year follow-up. Twenty-five patients were recruited with baseline systolic pulmonary artery pressure (PAP) of 49.5 ± 10.8 mm Hg. Systolic PAP results at 3, 6, 9, and 12 months were 39.1 ± 8.1, 30.4 ± 5.2, 27.7 ± 3.0, and 27.0 ± 4.7 mm Hg, respectively, which were all significantly lower than systolic PAP at baseline (P
- Subjects :
- Male
medicine.medical_specialty
Systole
Hypertension, Pulmonary
Vasodilator Agents
Occlusive disease
Administration, Oral
Observational Study
Pilot Projects
Walking
Ventricular Dysfunction, Left
03 medical and health sciences
0302 clinical medicine
Internal medicine
pulmonary hypertension
medicine
Humans
heart failure with reduced ejection fraction
In patient
Prospective Studies
Pulmonary Wedge Pressure
030212 general & internal medicine
beraprost
Prospective cohort study
Pulmonary wedge pressure
Aged
business.industry
General Medicine
medicine.disease
Epoprostenol
Pulmonary hypertension
Beraprost
Peripheral
Treatment Outcome
Echocardiography
030220 oncology & carcinogenesis
Exercise Test
Cardiology
Female
prognosis
business
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....86335de8041de4ef1ffdec19a35d4ca0