Electrochemically Modulated Liquid–Liquid Extraction for Sample Enrichment

Authors :: Bahruddin Saad
Afidah Abdul Rahim
Marc Hébrant
Grégoire Herzog
Maizatul Najwa Jajuli
M. Hazwan Hussin
Universiti Sains Malaysia (USM)
Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME)
Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Source :: Analytical Chemistry, Analytical Chemistry, American Chemical Society, 2019, 91 (11), pp.7466-7473. ⟨10.1021/acs.analchem.9b01674⟩
Publication Year :: 2019
Publisher :: American Chemical Society (ACS), 2019.
Abstract: International audience; A new sample preparation method is proposed for the extraction of pharmaceutical compounds (Metformin, Phenyl biguanide, and Phenformin) of varied hydrophilicity, dissolved in an aqueous sample. When in contact with an organic phase, an interfacial potential is imposed by the presence of an ion, tetramethylammonium (TMA +), common to each phase. The interfacial potential difference drives the transfer of ionic analytes across the interface and allows to reach up to nearly 100 % extraction efficiency and a 60-fold enrichment factor in optimised extraction conditions as it is determined by HPLC analysis. 2

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