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The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging
- Source :
- PLoS ONE, Vol 13, Iss 9, p e0203642 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- Background Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and noted as an independent risk factor for mortality in patients with SJS/TEN. To determine whether AKI staging can predict the outcome of patients with SJS/TEN, we compared the discriminative power of an AKI KDIGO staging system with that of SCROTEN, APACHE II, APACHE III, and SOFA. Materials and methods We retrospectively analyzed the data of 75 patients who were diagnosed with SJS, TEN, or SJS/TEN overlap syndrome at a tertiary care university hospital between January 1, 2011 and December 31, 2014. The baseline characteristics, biochemical analysis data, medication use, and outcomes of the patients were assessed, and the discriminative ability for predicting mortality was determined for each prognostic model. Results Of the 75 patients, 23 (30.7%) had AKI, of whom 13 (56.5%) died during the index admission. Of the prognostic risk models analyzed, the KDIGO staging system showed similar discriminative ability in predicting in-hospital mortality as did the other models. In addition, combining KDIGO with other scoring systems yielded significantly more accurate risk prediction for in-hospital mortality compared with the other individual scores alone, as measured by net reclassification index. The patients with KDIGO stages 2 and 3 exhibited a significantly lower 1-year survival rate than did those with KDIGO stages 0 and 1. Conclusion AKI KDIGO staging has good discriminative ability and is easy to utilize for predicting mortality.
- Subjects :
- Male
NSAIDs
030232 urology & nephrology
lcsh:Medicine
Pathology and Laboratory Medicine
0302 clinical medicine
Chronic Kidney Disease
Medicine and Health Sciences
Medicine
Urea
030212 general & internal medicine
lcsh:Science
Analgesics
Multidisciplinary
APACHE II
Organic Compounds
Mortality rate
Drugs
Overlap syndrome
Acute Kidney Injury
Middle Aged
Prognosis
Hospitals
Chemistry
Nephrology
Physical Sciences
Female
Anatomy
Research Article
medicine.medical_specialty
Death Rates
03 medical and health sciences
Signs and Symptoms
Population Metrics
Diagnostic Medicine
Internal medicine
Sepsis
Medical Dialysis
Humans
Risk factor
Survival rate
Survival analysis
Retrospective Studies
Pharmacology
Population Biology
business.industry
Organic Chemistry
lcsh:R
Chemical Compounds
Biology and Life Sciences
Retrospective cohort study
Kidneys
Renal System
medicine.disease
Survival Analysis
Toxic epidermal necrolysis
Pain management
Health Care
stomatognathic diseases
Health Care Facilities
Stevens-Johnson Syndrome
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....864fd66737d4bc99fdbd516319358bd7