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In silico analysis of putative dormancy genes in Plasmodium vivax
- Source :
- Acta Tropica. 186:24-34
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Plasmodium vivax is the most widely spread species causing human malaria. The control of malaria caused by P. vivax has been largely hampered by its ability to develop a dormant liver stage that can generate a new blood infection at different periods of time. Unfortunately, the mechanisms of dormancy in P. vivax have not been thoroughly elucidated to date. In this study, the putative dormancy genes were analyzed to select genes with less genetic variability to maintain the function of relapsing. Expression data concerning these genes were searched to support the selection. Protein interactions among selected gene products were identified based on known and predicted protein-protein interaction using String database. Potentially interacting proteins (n = 15) were used to propose a mechanism involved in dormancy based on the differential vesicular transport due to the iron available in the hepatocyte.
- Subjects :
- 0301 basic medicine
Veterinary (miscellaneous)
In silico
Plasmodium vivax
Protozoan Proteins
03 medical and health sciences
Recurrence
parasitic diseases
Malaria, Vivax
Humans
Computer Simulation
Genetic variability
Gene
Genetic Association Studies
Genetics
biology
Mechanism (biology)
biology.organism_classification
Vesicular transport protein
030104 developmental biology
Infectious Diseases
Insect Science
Host-Pathogen Interactions
Dormancy
Parasitology
Function (biology)
Subjects
Details
- ISSN :
- 0001706X
- Volume :
- 186
- Database :
- OpenAIRE
- Journal :
- Acta Tropica
- Accession number :
- edsair.doi.dedup.....8656ab7a12a050e67a495617edd8a433