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Treatments for the amelioration of persistent factors in complex anal fistula
- Source :
- Biotechnology Letters. 44:23-31
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Anal fistulae are abnormal hollow connections between the wall of the anal canal and the perianal skin around the anus that have remained a burden on the medical sector for centuries. The complexity of this disease is attributed to a number of factors such as the degree of associated sphincter muscle, concomitant illnesses, existence of multiple fistulous tracts and the number of previous interventions. Persistence of a complex anal fistula can cause a decline in patient's physical quality of life as well as impact on the psychological status of patients who often suffer from anxiety and depression. Surgical intervention remains the gold standard for treatment, however; the risk of incontinence and high recurrence potential has led to interest into developing alternative treatment approaches such as the use of biologics, bioactives and biomaterials. One potential reason for these varied outcomes could be the multifactorial interplay between genetic, immune-related, environmental, and microbial persistence factors on tissue regeneration. Recent observations have proposed that adverse inflammatory mediators may contribute more than microbial factors. The moderate to high success rates of biotechnological advances (mesenchymal stem cells and biomaterial scaffolds) show promise as therapies for the amelioration of adverse persistent factors while facilitating a means to closing the fistula tract. The purpose of this review is to outline recent advances in biologics and combination therapies to treat persistent factors associated with complex anal fistula.
- Subjects :
- Anal fistula
medicine.medical_specialty
Fistula
Anal Canal
Bioengineering
Stem cells
Disease
Biologics
Applied Microbiology and Biotechnology
Persistence
Quality of life
medicine
Humans
Rectal Fistula
Tissue engineering
Intensive care medicine
Depression (differential diagnoses)
business.industry
Mesenchymal Stem Cells
General Medicine
Anal canal
medicine.disease
Anus
Treatment Outcome
medicine.anatomical_structure
Drug delivery
Quality of Life
Materials Research Institute AIT
Anxiety
medicine.symptom
business
Biotechnology
Subjects
Details
- ISSN :
- 15736776 and 01415492
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Biotechnology Letters
- Accession number :
- edsair.doi.dedup.....8668b490b83b98b509dece20a6857de0