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Concordance and Clinical Significance of Uncommon Variants of Bladder Urothelial Carcinoma in Transurethral Resection and Radical Cystectomy Specimens
- Publication Year :
- 2014
-
Abstract
- To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens. METHODS Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate. RESULTS Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P
- Subjects :
- Male
URINARY-BLADDER
CANCER
UPDATE
IMPACT
DIFFERENTIATION
medicine.medical_treatment
Kaplan-Meier Estimate
Settore MED/24 - Urologia
Retrospective Studie
Bladder cancer, histologic variants
bladder urothelial carcinoma
Urinary bladder
Medicine (all)
Middle Aged
Prognosis
medicine.anatomical_structure
Treatment Outcome
Urinary Bladder Neoplasm
bladder cancer
Female
Human
medicine.medical_specialty
Prognosi
Concordance
Urology
Urinary Bladder
Cystectomy
Disease-Free Survival
Follow-Up Studie
medicine
Carcinoma
Humans
Clinical significance
Aged
Follow-Up Studies
Proportional Hazards Models
Retrospective Studies
Urinary Bladder Neoplasms
Bladder cancer
Proportional hazards model
business.industry
Cancer
medicine.disease
Proportional Hazards Model
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....866cbb0aa81123475a56622a1162b405