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Small fiber neuropathy associated with <scp>SARS‐CoV</scp> ‐2 infection
- Source :
- Muscle & Nerve
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Introduction/Aims The development and persistence of neurological symptoms following severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is referred to as “long‐haul” syndrome. We aimed to determine whether small fiber neuropathy (SFN) was associated with SARS‐CoV‐2 infection. Methods We retrospectively studied the clinical features and outcomes of patients who were referred to us between May 2020 and May 2021 for painful paresthesia and numbness that developed during or after SARS‐CoV‐2 infection and who had nerve conduction studies showing no evidence of a large fiber polyneuropathy. Results We identified 13 patients, Eight women and five men with age ranging from 38–67 y. Follow‐up duration ranged from 8 to 12 mo. All patients developed new‐onset paresthesias within 2 mo following SARS‐CoV‐2 infection, with an acute onset in seven and co‐existing autonomic symptoms in seven. Three patients had pre‐existing but controlled neuropathy risk factors. Skin biopsy confirmed SFN in six, all of whom showed both neuropathy symptoms and signs, and two also showed autonomic dysfunction by autonomic function testing (AFT). Of the remaining seven patients who had normal skin biopsies, six showed no clinical neuropathy signs and one exhibited signs and had abnormal AFT. Two patients with markedly reduced intraepidermal nerve fiber densities and one with normal skin biopsy had severe and moderate coronavirus disease 2019 (COVID‐19); the remainder experienced mild COVID‐19 symptoms. Nine patients received symptomatic neuropathy treatment with paresthesias controlled in seven (77.8%). Discussion Our findings suggest that symptoms of SFN may develop during or shortly after COVID‐19. SFN may underlie the paresthesias associated with long‐haul post‐COVID‐19 symptoms.
- Subjects :
- medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
small fiber neuropathy
Physiology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Nerve fiber
SARS‐CoV‐2
neurological complications
Cellular and Molecular Neuroscience
Acute onset
post‐acute COVID‐19 syndrome
Physiology (medical)
Internal medicine
Biopsy
medicine
Small Fiber Neuropathy
medicine.diagnostic_test
business.industry
long‐haul COVID‐19 symptoms
medicine.disease
medicine.anatomical_structure
Clinical Research Short Report
Skin biopsy
Neurology (clinical)
business
Polyneuropathy
Subjects
Details
- ISSN :
- 10974598 and 0148639X
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Muscle & Nerve
- Accession number :
- edsair.doi.dedup.....867164ed8b194f9b0e46bc4acc32e2b5