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Rapid hyperspectral fluorescence lifetime imaging

Authors :
Christopher Dunsby
Pieter A.A. De Beule
Richard K.P. Benninger
Hugh B. Manning
M. John Lever
Ian Munro
Jose Requejo-Isidro
Dylan M. Owen
Daniel S. Elson
Praveen Anand
James McGinty
Mark A. A. Neil
Paul M. W. French
Clifford Talbot
Source :
Microscopy Research and Technique. 70:481-484
Publication Year :
2007
Publisher :
Wiley, 2007.

Abstract

We report a rapid hyperspectral fluorescence lifetime imaging (FLIM) instrument that exploits high-speed FLIM technology in a line-scanning microscope. We demonstrate the acquisition of whole-field optically sectioned hyperspectral fluorescence lifetime image stacks (with 32 spectral bins) in less than 40 s and illustrate its application to unstained biological tissue. Microsc. Res. Tech., 2007. © 2007 Wiley-Liss, Inc.

Details

ISSN :
10970029 and 1059910X
Volume :
70
Database :
OpenAIRE
Journal :
Microscopy Research and Technique
Accession number :
edsair.doi.dedup.....867363726d3d0fcb60a1fc3e278e1388
Full Text :
https://doi.org/10.1002/jemt.20434