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Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper
- Source :
- Bioscience Reports, Vol 33, Iss 4, p e00049 (2013), Scopus-Elsevier, Bioscience Reports
- Publication Year :
- 2013
- Publisher :
- Portland Press, Biochemical Society, 2013.
-
Abstract
- The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells. © 2013 The Author(s).
- Subjects :
- PDE, phosphodiesterase
lcsh:Life
lcsh:QR1-502
Review Article
Nrf2, nuclear factor-erythroid 2-related factor 2
TNF, tumour necrosis factor
Biochemistry
lcsh:Microbiology
0302 clinical medicine
DC, dendritic cells
Macrophage
Cation Transport Proteins
innate immunity
IKKβ, IκB (inhibitor of nuclear factor κB) kinase β
0303 health sciences
Toll-like receptor
Bacterial Infections
Antimicrobial
3. Good health
MMP, matrix metalloproteinase
Zinc
CTR, copper transporter
monocyte
copper transporter (CTR)
LPS, lipopolysaccharide
NF-κB, nuclear factor κB
FPN1, ferroportin 1
TLR, Toll-like receptor
GPI, glycosylphosphatidylinositol
Biochemistry & Molecular Biology
host defence
zinc transporter
Biophysics
IFNγ, interferon γ
chemistry.chemical_element
Biology
S3
03 medical and health sciences
ROS, reactive oxygen species
Immune system
Immunity
SOD, superoxide dismutase
Animals
Humans
Molecular Biology
030304 developmental biology
TRIF, TIR (Toll/interleukin-1 receptor) domain-containing adaptor protein inducing interferon β
Innate immune system
Macrophages
Transporter
Biological Transport
Cell Biology
MT, metallothionein
Immunity, Innate
IL, interleukin
lcsh:QH501-531
chemistry
Gene Expression Regulation
CP, ceruloplasmin
Dietary Supplements
MAPK, mitogen-activated protein kinase
030217 neurology & neurosurgery
Copper
Subjects
Details
- Language :
- English
- ISSN :
- 15734935 and 01448463
- Volume :
- 33
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....867cebb3d5a32f9e9bb61fd2445ba627