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Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus
- Source :
- American Journal of Gastroenterology, 101(7), 1421-1429. Springer Nature
- Publication Year :
- 2006
-
Abstract
- OBJECTIVE: To identify risk factors for esophageal adenocarcinoma (EAC) in patients with Barrett’s esophagus (BE). METHODS: A hospital-based case-control study was performed in which 91 cases with EAC and 244 controls with histologically confirmed BE (>2 cm) with no dysplasia or low-grade dysplasia were included. Information on demographic, anthropometric, and lifestyle characteristics, physical activity levels, working posture, family history, gastroesophageal reflux disease (GERD) symptoms, and medication use was collected by questionnaire. RESULTS: Cases more often were current smokers (odds ratio 3.7, 95% confidence interval 1.4‐9.9), more often had a body mass index >25 assessed at age 20 (2.6, 1.2‐5.5), and more frequently had been working in a stooped posture at age 20 (2.0, 1.1‐3.9), compared to controls. In addition, cases less often experienced symptoms of heartburn (0.3, 0.2‐0.5) and less frequently used proton pump inhibitors (0.1, 0.05‐0.2), compared to controls, whereas use of nonsteroidal anti-inflammatory drugs/aspirin was more common among cases (1.8, 1.1‐3.2). Cases more often were men, compared to controls (91% vs 67%, p < 0.001). CONCLUSION: In patients with BE, the risk of EAC is related to risk factors for GERD, which is, however, asymptomatic. As these risk factors are common in Western countries, they are probably not helpful in individualization of surveillance intervals.
- Subjects :
- Male
medicine.medical_specialty
Esophageal Neoplasms
Posture
Adenocarcinoma
Gastroenterology
Body Mass Index
Barrett Esophagus
Risk Factors
Internal medicine
Surveys and Questionnaires
medicine
Humans
Risk factor
Netherlands
Chi-Square Distribution
Hepatology
business.industry
Esophageal disease
Anti-Inflammatory Agents, Non-Steroidal
Smoking
Case-control study
Heartburn
Odds ratio
Middle Aged
medicine.disease
Anti-Ulcer Agents
Logistic Models
Dysplasia
Barrett's esophagus
Case-Control Studies
GERD
Educational Status
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 00029270
- Database :
- OpenAIRE
- Journal :
- American Journal of Gastroenterology, 101(7), 1421-1429. Springer Nature
- Accession number :
- edsair.doi.dedup.....867f91d90d2e45ac191ae48da75050e3