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AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper
- Source :
- Allergy, Allergy, 74(6), 1037. Blackwell Publishing Ltd, Untersmayr, E, Bax, H J, Bergmann, C, Bianchini, R, Cozen, W, Gould, H J, Hartmann, K, Josephs, D H, Levi-Schaffer, F, Penichet, M L, O'Mahony, L, Poli, A, Redegeld, F A, Roth-Walter, F, Turner, M C, Vangelista, L, Karagiannis, S N & Jensen-Jarolim, E 2019, ' AllergoOncology: Microbiota in allergy and cancer : a European Academy for Allergy and Clinical Immunology position paper ', Allergy, vol. 74, no. 6, pp. 1037-1051 . https://doi.org/10.1111/all.13718
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
- Subjects :
- 0301 basic medicine
Male
Allergy
Disease
hygiene hypothesis
Epithelium
Immune tolerance
0302 clinical medicine
oncoimmunology
Neoplasms
Immunology and Allergy
Medicine
Micronutrients
Child
Phylogeny
Cancer
Immunity, Cellular
Microbiota
3. Good health
Child, Preschool
Female
Oncoimmunology
Position Paper
Immunology
03 medical and health sciences
Immune system
Hygiene hypothesis
Immunity
microbiota
cancer
Animals
Humans
Microbiome
Mucous Membrane
Bacteria
Host Microbial Interactions
business.industry
Infant
biochemical phenomena, metabolism, and nutrition
medicine.disease
allergy
Asthma
Diet
Gastrointestinal Microbiome
030104 developmental biology
030228 respiratory system
Hygience hypothesis
bacteria
business
Subjects
Details
- Language :
- English
- ISSN :
- 13989995 and 01054538
- Volume :
- 74
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi.dedup.....8691b9e23643a186fa65c159380ea119