Antihypertensive effects of lactoferrin hydrolyzates: Inhibition of angiotensin- and endothelin-converting enzymes

The potential of bovine lactoferrin (LF) as a source of antihypertensive peptides acting on the renin-angiotensin system (RAS) and the endothelin (ET) system as dual vasopeptidase inhibitors has been examined. For this purpose enzymatic LF hydrolyzates (LFHs) were generated by trypsin and proteinase K digestions. Permeate fractions with molecular masses lower than 3 kDa (LFH
This work was supported by grants AGL2007-64672/ALI and AGL2010-21009 from ‘Ministerio de Educación y Ciencia - FEDER’, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063, and RETICS RD06/0026/0006 from ‘Instituto de Salud Carlos III’. R. Fernández-Musoles is recipient of a fellowship from ‘Ministerio de Educación y Ciencia’ (BES-2008-004472).