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Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus
- Source :
- Journal of diabetes and its complications. 34(4)
- Publication Year :
- 2019
-
Abstract
- Aims To examine for differences in circulating progenitor cells (CPCs) and endothelial progenitor cells (EPCs) in patients with and without diabetic peripheral neuropathy (DPN). Methods A total of 105 participants were included: 50 patients with type 2 diabetes (T2DM) and DPN, 30 patients with T2DM without DPN and 25 healthy individuals. CPCs and 6 different EPCs phenotypes were assessed with flow cytometry. We also measured plasma levels of vascular endothelial growth factor (VEGF), stromal cell-derived factor 1 (SDF-1), vascular cell adhesion protein-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM) and tumor necrosis factor a (TNFa). Results No difference was observed in the number of CPCs among the 3 groups. Patients with DPN had higher numbers of all 6 EPCs phenotypes when compared with patients without DPN and higher number of 5 EPCs phenotypes when compared with healthy individuals. Plasma VEFG, VCAM-1, ICAM-1 and TNFa levels did not differ among the 3 groups. Patients with DPN had lower SDF-1 levels in comparison with healthy individuals. Conclusion Circulating EPCs are increased while SDF-1 levels are decreased in the presence of DPN. Our findings suggest that DPN may be associated with impaired trafficking of EPCs and impaired EPCs homing to the injured endothelium.
- Subjects :
- Adult
Male
medicine.medical_specialty
Stromal cell
Endothelium
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Diabetic Neuropathies
Internal medicine
Diabetes mellitus
Internal Medicine
Medicine
Humans
Progenitor cell
Aged
Endothelial Progenitor Cells
business.industry
Peripheral Nervous System Diseases
Middle Aged
medicine.disease
Flow Cytometry
Vascular endothelial growth factor
Peripheral neuropathy
medicine.anatomical_structure
Cross-Sectional Studies
chemistry
Diabetes Mellitus, Type 2
Case-Control Studies
cardiovascular system
Tumor necrosis factor alpha
Female
business
Subjects
Details
- ISSN :
- 1873460X
- Volume :
- 34
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of diabetes and its complications
- Accession number :
- edsair.doi.dedup.....86c8dd1842a3bdf5eae05914c32dd664