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lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2020
- Publisher :
- Spandidos Publications, 2020.
-
Abstract
- Acute gouty arthritis (AGA) is characterized by the accumulation of pro‑inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non‑coding RNA (lncRNA)‑MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA‑MM2P regulates the MSU‑induced inflammatory process. In cell models of RAW 264.7 and THP‑1‑derived macrophages, decreased expression of lncRNA‑MM2P was observed in lipopolysaccharide‑ and MSU‑treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA‑MM2P led to the upregulation of MSU‑mediated inflammatory responses, both in RAW 264.7 and THP‑1‑derived macrophages. In conclusion, lncRNA‑MM2P could be an important regulator of MSU‑induced inflammation, and therefore could be involved in the development of AGA.
- Subjects :
- Lipopolysaccharides
0301 basic medicine
Cancer Research
Small interfering RNA
monosodium urate-induced inflammation
Lipopolysaccharide
THP-1 Cells
Cell
Regulator
Down-Regulation
Inflammation
Models, Biological
Biochemistry
Proinflammatory cytokine
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
acute gouty arthritis
Genetics
medicine
Animals
Humans
Molecular Biology
long non-coding RNA-MM2P
Gene knockdown
Arthritis, Gouty
business.industry
Articles
Uric Acid
RAW 264.7 Cells
030104 developmental biology
medicine.anatomical_structure
Oncology
chemistry
regulator
Gene Knockdown Techniques
030220 oncology & carcinogenesis
Immunology
Cytokines
Molecular Medicine
RNA, Long Noncoding
medicine.symptom
business
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....86d8afdb0377055d94b5e307aa8106cd