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Early events in spontaneous neutrophil apoptosis
- Source :
- Biochemical Society Transactions. 32:461-464
- Publication Year :
- 2004
- Publisher :
- Portland Press Ltd., 2004.
-
Abstract
- Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neutrophils gradually lose the anti-apoptotic protein Mcl-1 and Bax translocates and inserts into the mitochondrial membrane. However, other reports show that caspase 8 is required for neutrophil apoptosis, suggesting the involvement of DR (death receptor) signalling. As DR ligation is not required for neutrophil apoptosis, this raises the intriguing possibility that activation of caspase 8 during neutrophil apoptosis occurs via a novel mechanism. In the present paper, we discuss the current evidence for mechanisms occurring in neutrophil apoptosis, which could trigger DR signalling in the absence of DR ligation.
- Subjects :
- Neutrophils
Apoptosis
Inflammation
Caspase 8
Models, Biological
Biochemistry
Membrane Microdomains
Bcl-2-associated X protein
Leukocytes
medicine
Animals
Humans
Cycloheximide
Inner mitochondrial membrane
Receptor
bcl-2-Associated X Protein
Protein Synthesis Inhibitors
Dose-Response Relationship, Drug
biology
Mitochondria
Neoplasm Proteins
Transport protein
Cell biology
Protein Transport
Proto-Oncogene Proteins c-bcl-2
Caspases
biology.protein
Myeloid Cell Leukemia Sequence 1 Protein
medicine.symptom
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 14708752 and 03005127
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Biochemical Society Transactions
- Accession number :
- edsair.doi.dedup.....86e6d318413e328a98938a2ab73a7293
- Full Text :
- https://doi.org/10.1042/bst0320461