Back to Search
Start Over
The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 7910, p 7910 (2021), International Journal of Molecular Sciences, Volume 22, Issue 15
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, the genus Ferula L. is one of the most representative, and ferutinin, the most common sesquiterpene, is extracted from the leaves, rhizome, and roots of this plant. As reported in the scientific literature, ferutinin possesses antioxidant and anti-inflammatory properties, as well as valuable estrogenic properties. Neurodegenerative and demyelinating diseases are devastating conditions for which a definite cure has not yet been established. The mechanisms involved in these diseases are still poorly understood, and oxidative stress is considered to be both a key modulator and a common denominator. In the proposed experimental system, co-cultured human neurons (SH-SY5Y) and human oligodendrocytes (MO3.13) were treated with the pro-inflammatory agent lipopolysaccharide at a concentration of 1 μg/mL for 24 h or pretreated with ferutinin (33 nM) for 24 h and subsequently exposed to lipopolysaccharide 1 μg/mL for 24 h. Further studies would, however, be needed to establish whether this natural compound can be used as a support strategy in pathologies characterized by progressive inflammation and oxidative stress phenomena.
- Subjects :
- 0301 basic medicine
Antioxidant
Lipopolysaccharide
QH301-705.5
medicine.medical_treatment
oligodendrocytes
neurons
Pharmacology
Sesquiterpene
medicine.disease_cause
Catalysis
Inorganic Chemistry
Terpene
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
demyelinating pathologies
medicine
oxidative stress
Ferula communis
Physical and Theoretical Chemistry
Biology (General)
ferutinin
Molecular Biology
QD1-999
Spectroscopy
Neuroinflammation
biology
Organic Chemistry
General Medicine
biology.organism_classification
Computer Science Applications
Rhizome
Chemistry
030104 developmental biology
chemistry
inflammation
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 7910
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....870b61ea359a9e4f4792414c5756d0d8