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The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes

Authors :
Francesca Bosco
Saverio Nucera
Roberta Macrì
Micaela Gliozzi
Sara Ilari
Maria Caterina Zito
Vincenzo Mollace
Vincenzo Musolino
Miriam Scicchitano
Ernesto Palma
Jessica Maiuolo
Francesca Oppedisano
Irene Bava
Carolina Muscoli
Cristina Carresi
Stefano Ruga
Federica Scarano
Source :
International Journal of Molecular Sciences, Vol 22, Iss 7910, p 7910 (2021), International Journal of Molecular Sciences, Volume 22, Issue 15
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

In recent decades, interest in natural compounds has increased exponentially due to their numerous beneficial properties in the treatment of various acute and chronic diseases. A group of plant derivatives with great scientific interest is terpenic compounds. Among the plants richest in terpenes, the genus Ferula L. is one of the most representative, and ferutinin, the most common sesquiterpene, is extracted from the leaves, rhizome, and roots of this plant. As reported in the scientific literature, ferutinin possesses antioxidant and anti-inflammatory properties, as well as valuable estrogenic properties. Neurodegenerative and demyelinating diseases are devastating conditions for which a definite cure has not yet been established. The mechanisms involved in these diseases are still poorly understood, and oxidative stress is considered to be both a key modulator and a common denominator. In the proposed experimental system, co-cultured human neurons (SH-SY5Y) and human oligodendrocytes (MO3.13) were treated with the pro-inflammatory agent lipopolysaccharide at a concentration of 1 μg/mL for 24 h or pretreated with ferutinin (33 nM) for 24 h and subsequently exposed to lipopolysaccharide 1 μg/mL for 24 h. Further studies would, however, be needed to establish whether this natural compound can be used as a support strategy in pathologies characterized by progressive inflammation and oxidative stress phenomena.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
22
Issue :
7910
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....870b61ea359a9e4f4792414c5756d0d8