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Evaluating Biventricular Myocardial Velocity and Interventricular Dyssynchrony in Adult Patients During the First Year After Heart Transplantation
- Source :
- Journal of magnetic resonance imaging : JMRIREFERENCES. 52(3)
- Publication Year :
- 2019
-
Abstract
- Magnetic resonance tissue phase mapping (TPM) measures three-directional myocardial velocities of the left and right ventricle (LV, RV). This noninvasive technique may supplement endomyocardial biopsy (EMB) in monitoring grafts post-heart transplantation (HTx).To assess biventricular myocardial velocity alterations in grafts and investigate the relationship between velocities and acute cellular rejection (ACR) episodes.Prospective.Twenty-seven patients within 1 year post-HTx (49 ± 13 years, 19 M) and 18 age-matched controls (49 ± 15 years, 12 M).1.5T, 2D balanced steady-state free precession, and TPM.Ventricular function: end-diastolic and end-systolic volumes, stroke volumes, ejection fraction (EF), and myocardial mass. TPM velocities: peak-systolic and peak-diastolic velocities, cardiac twist, and interventricular dyssynchrony. ACR rejection episodes: International Society for Heart and Lung Transplantation grading of EMB specimens.The Lilliefors test for normality, unpaired t-tests, and Wilcoxon rank-sum tests for normally and nonnormally distributed data, respectively, were used, as well as multivariate regression for confounding variables and Pearson's correlation for associations between TPM velocities and global function.Compared to controls, HTx patients demonstrated reduced biventricular systolic longitudinal velocities (LV: 5.2 ± 2.1 vs. 4.0 ± 1.5 cm/s, P 0.05; RV: 4.2 ± 1.3 vs. 3.1 ± 1.2 cm/s, P 0.01). Correlation analysis revealed significant positive relationships for biventricular EF with radial peak velocities of the same ventricle in both systole and diastole (LV systole: r = 0.48, P 0.01; LV diastole: r = 0.28, P 0.05; RV systole: r = 0.35, P 0.01; RV diastole: r = 0.36, P 0.01). Segmentally, longitudinal velocities were impaired in 7/16 LV segments and 5/10 RV segments in systole and 7/10 RV segments in diastole. TPM analysis in studies with4 preceding ACR episodes showed globally reduced RV and LV systolic radial velocity, and segmentally reduced radial and longitudinal systolic velocities.Biventricular global and segmental velocities were reduced in HTx patients. Patients with4 rejection episodes showed reduced myocardial velocities. The TPM sequence may add functional information for monitoring graft dysfunction.2 TECHNICAL EFFICACY STAGE: 2 J. Magn. Reson. Imaging 2020;52:920-929.
- Subjects :
- Adult
medicine.medical_specialty
Systole
medicine.medical_treatment
Heart Ventricles
030218 nuclear medicine & medical imaging
03 medical and health sciences
Ventricular Dysfunction, Left
0302 clinical medicine
Diastole
Internal medicine
medicine
Lung transplantation
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
Stroke
Heart transplantation
Ejection fraction
medicine.diagnostic_test
business.industry
Myocardium
Confounding
Magnetic resonance imaging
Middle Aged
medicine.disease
Transplantation
medicine.anatomical_structure
Ventricle
Cardiology
Heart Transplantation
business
Subjects
Details
- ISSN :
- 15222586
- Volume :
- 52
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of magnetic resonance imaging : JMRIREFERENCES
- Accession number :
- edsair.doi.dedup.....8716cbde0b033f6412b0810ac02b7318