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Expansion of the Antigenic Repertoire of a Single T Cell Receptor upon T Cell Activation
- Source :
- The Journal of Immunology. 167:655-666
- Publication Year :
- 2001
- Publisher :
- The American Association of Immunologists, 2001.
-
Abstract
- Activated T cells and their naive precursors display different functional avidities for peptide/MHC, but are thought to have identical antigenic repertoires. We show that, following activation with a cognate mimotope (NRP), diabetogenic CD8+ T cells expressing a single TCR (8.3) respond vigorously to numerous peptide analogs of NRP that were unable to elicit any responses from naive 8.3-CD8+ T cells, even at high concentrations. The NRP-reactive, in vivo activated CD8+ cells arising in pancreatic islets of nonobese diabetic mice are similarly promiscuous for peptide/MHC, and paradoxically this promiscuity expands as the aviditiy of the T cell population for NRP/MHC increases with age. Thus, activation and avidity maturation of T lymphocyte populations can lead to dramatic expansions in the range of peptides that elicit functional T cell responses.
- Subjects :
- T cell
Molecular Sequence Data
Immunology
Receptors, Antigen, T-Cell
Mice, Transgenic
chemical and pharmacologic phenomena
Streptamer
CD8-Positive T-Lymphocytes
Biology
Lymphocyte Activation
Major histocompatibility complex
Prediabetic State
Interferon-gamma
Islets of Langerhans
Mice
Mice, Inbred NOD
Tumor Cells, Cultured
medicine
Animals
Immunology and Allergy
Cytotoxic T cell
Amino Acid Sequence
Antigens
Cells, Cultured
Mice, Knockout
Hybridomas
Membrane Glycoproteins
Calcium-Binding Proteins
CD28
Cell Differentiation
T lymphocyte
MHC restriction
Molecular biology
Peptide Fragments
Clone Cells
Diabetes Mellitus, Type 1
medicine.anatomical_structure
Amino Acid Substitution
biology.protein
Interleukin-2
CD8
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....8719d4e0c325b16cc49f1b57b668f607