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Resistance of aspirin during and after pregnancy: A longitudinal cohort study
- Source :
- bij de Weg, J M, Abheiden, C N H, Fuijkschot, W W, Harmsze, A M, de Boer, M A, Thijs, A & de Vries, J I P 2020, ' Resistance of aspirin during and after pregnancy: A longitudinal cohort study ', Pregnancy Hypertension, vol. 19, pp. 25-30 . https://doi.org/10.1016/j.preghy.2019.11.008, Pregnancy Hypertension, 19, 25-30. Elsevier BV
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objectives The objective of this study is to investigate possible changes in aspirin resistance during and after pregnancy over time. Study design A longitudinal cohort study in obstetric high risk women with an indication for aspirin usage during pregnancy to prevent placenta mediated pregnancy complications. Main outcome measures Aspirin resistance measured in the first, second and third trimester of pregnancy and at least three months postpartum by four complementary test: PFA-200, VerifyNow®, Chronolog light transmission aggregometry (Chronolog LTA) and serum thromboxane B2 (TxB2) level measurements. Correlation between the devices was investigated. Results In total, 23 pregnant women participated in the present study. Aspirin resistance according to the PFA-200, VerifyNow®, Chronolog LTA and serum TxB2, was 30.4%, 17.4%, 26.1% and 23.8% respectively. Resistance by any device was 69.6%. Aspirin resistance measured by the VerifyNow®, Chronolog LTA, serum TxB2 and aspirin resistance by any device during pregnancy was demonstrated more frequently than aspirin resistance after pregnancy. Correlation between the different devices was weak. Conclusion Aspirin resistance was found in a considerable part of the participants. Considerable variation between participants, within participants over time and between the different devices was found. Prevalence of aspirin resistance during pregnancy differs from after pregnancy. More research on aspirin resistance and clinical obstetric outcome is needed.
- Subjects :
- Adult
Light transmission
medicine.medical_specialty
Platelet Function Tests
Drug Resistance
Drug resistance
030204 cardiovascular system & hematology
Third trimester
Cohort Studies
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Internal medicine
Placenta
Internal Medicine
medicine
Humans
Longitudinal Studies
Longitudinal cohort
Aspirin
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
Hypertension, Pregnancy-Induced
medicine.disease
Thromboxane B2
medicine.anatomical_structure
chemistry
Female
Pregnancy Trimesters
business
Platelet Aggregation Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 22107789
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Pregnancy Hypertension
- Accession number :
- edsair.doi.dedup.....872c056c896af57b39978c87458f9fff