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Growth hormone treatment impact on growth rate and final height of patients who received HSCT with TBI or/and cranial irradiation in childhood: a report from the French Leukaemia Long-Term Follow-Up Study (LEA)
- Source :
- Bone Marrow Transplantation. 47:684-693
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- The literature contains a substantial amount of information about factors that adversely influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and/or cranial irradiation (CI) for acute leukaemia (AL). By contrast, only a few studies have evaluated the impact of growth hormone (GH) therapy on growth rate and final height (FH) in these children. We evaluated growth rates during the pre- and post-transplant periods to FH in a group of 25 children treated with HSCT (n=22), TBI (n=21) or/and CI (n=8) for AL and receiving GH therapy. At the start of GH treatment, the median height Z-score was -2.19 (-3.95 to 0.02), significantly lower than at AL diagnosis (P
- Subjects :
- Male
medicine.medical_specialty
Myeloid
Gastroenterology
Internal medicine
medicine
Humans
Growth rate
Child
Retrospective Studies
Transplantation
Human Growth Hormone
business.industry
Final height
Hematopoietic Stem Cell Transplantation
Infant
Retrospective cohort study
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Body Height
Growth hormone treatment
Leukemia, Myeloid, Acute
Leukemia
medicine.anatomical_structure
Graft-versus-host disease
Endocrinology
Child, Preschool
Female
Cranial Irradiation
business
Whole-Body Irradiation
Follow-Up Studies
Subjects
Details
- ISSN :
- 14765365 and 02683369
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....874ff5c01d6f1f33ab2d4c0ca34e07fb
- Full Text :
- https://doi.org/10.1038/bmt.2011.139