Back to Search Start Over

(−)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions

Authors :
Yu Fu
Zi-Tao Zhu
Guo-Zhang Jin
Source :
Trends in Pharmacological Sciences. 23:4-7
Publication Year :
2002
Publisher :
Elsevier BV, 2002.

Abstract

(−)-Stepholidine (SPD), an active ingredient of the Chinese herb Stephania, is a dopamine D1 receptor agonist and a D2 receptor antagonist. The dual actions of SPD have been demonstrated in both cortical and subcortical structures, including the medial prefrontal cortex (mPFC), nucleus accumbens, ventral tegmental area and basal ganglia dopamine systems. D1 receptor dysfunction in the mPFC and D2 receptor hyperactivity in the subcortex are thought to occur in sufferers of schizophrenia. Thus, the dual effects of SPD suggest that this compound might represent a novel antipsychotic agent.

Details

ISSN :
01656147
Volume :
23
Database :
OpenAIRE
Journal :
Trends in Pharmacological Sciences
Accession number :
edsair.doi.dedup.....87894402a7ec146fdefad87003c23f18