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Peroral Cholangioscopy-Guided Forceps Biopsy and Endoscopic Scraper for the Diagnosis of Indeterminate Extrahepatic Biliary Stricture
- Source :
- Journal of Clinical Medicine, Volume 8, Issue 6, Journal of Clinical Medicine, Vol 8, Iss 6, p 873 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Background: Peroral cholangioscopy (POCS) has become a widely-used technique in diagnosing indeterminate biliary strictures, enabling optical viewing of the biliary system and targeted biopsies under direct vision. The diagnostic utility of the new endoscopic scraper, Trefle&reg<br />for extrahepatic cholangiocarcinoma (ECC) has also been reported. However, the diagnostic utility of POCS-guided and Trefle&reg<br />assisted tissue acquisition for ECC has never been compared empirically. We evaluated the efficacy and safety of Trefle&reg<br />assisted tissue acquisition for diagnosing ECC compared with POCS-guided tissue sampling. Methods: Patients who underwent Trefle&reg<br />assisted tissue acquisition or POCS-guided forceps biopsy to differentiate ECC from benign biliary disease between April 2014 and March 2018 were enrolled retrospectively. We evaluated the diagnostic performance of Trefle&reg<br />assisted tissue acquisition and POCS-guided forceps biopsy based on pathological evaluation. We also compared adverse events associated with Trefle&reg<br />assisted tissue acquisition with those of POCS-guided forceps biopsy. Results: We enrolled 34 patients with biliary disease and performed Trefle&reg<br />assisted tissue acquisition and POCS-guided forceps biopsy in 14 and 20 patients, respectively. Sensitivity, specificity, and accuracy of Trefle&reg<br />assisted tissue acquisition were 87.5%, 83.3%, and 85.7%, respectively, and for POCS-guided forceps biopsy, these were 90.0% each. Statistical values of Trefle&reg<br />assisted tissue acquisition and POCS-guided tissue acquisition were not significantly different. There were no significant differences in the occurrence of adverse events between the Trefle&reg<br />assisted tissue acquisition and the POCS-guided forceps biopsy (35.7% vs. 25.0%, p = 0.770). Compared with patients who underwent POCS procedure, endoscopic sphincterotomy was performed for fewer patients who underwent Trefle&reg<br />assisted tissue acquisition (p &lt<br />0.001). Conclusions: The diagnostic ability of Trefle&reg<br />assisted tissue acquisition for ECC is similar to that of POCS-guided tissue acquisition. Trefle&reg<br />assisted tissue acquisition might also help to preserve the sphincter of Oddi and its digestive function.
- Subjects :
- medicine.medical_specialty
genetic structures
adverse event
lcsh:Medicine
Article
Biliary disease
Extrahepatic Cholangiocarcinoma
03 medical and health sciences
0302 clinical medicine
peroral cholangioscopy
Sphincter of Oddi
medicine
trefle
Forceps biopsy
accuracy
business.industry
lcsh:R
General Medicine
Tissue sampling
medicine.disease
eye diseases
Tissue acquisition
030220 oncology & carcinogenesis
Direct vision
030211 gastroenterology & hepatology
Radiology
cholangiocarcinoma
business
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....87895c8dc5c6f70d17797b97b1393f39