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THE ROLE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN PERIODONTAL DISEASE
- Source :
- Scopus-Elsevier
- Publication Year :
- 2010
- Publisher :
- BIOLIFE SAS, 2010.
-
Abstract
- The anti-Cyclic Citrullinated Peptide Antibodies (anti-CCP) are produced locally in the inflamed synovium of Rheumatoid arthritis (RA) patients, suggesting that citrullinated proteins are located in the inflamed synovium. In scientific literature were find periodontal bacterial DNA in serum and synovial fluid of RA with PD patients. RA and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings RA. One oral pathogen strongly implicated in the pathogenesis of periodontal disease (PD), Porphyromonas. gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. Under this point of view, we speculate about the presence of anti-CCP antibodies in sera of PD with RA patients. We conducted this study to evaluate and compare the diagnostic and predictive utility of anti-CCP antibodies in patients with PD and patients with PD and RA. Anti-CCP antibody was not found in 21 sera (U/ml
- Subjects :
- Adult
Male
musculoskeletal diseases
Immunology
Arthritis
anti-cyclic citrullinated peptide antibodies
rheumatoid arthritis
periodontal disease
peptidylarginine deiminase
Peptide
Peptides, Cyclic
Anti-cyclic citrullinated peptide antibodie
Arthritis, Rheumatoid
Pathogenesis
medicine
Humans
Immunology and Allergy
Synovial fluid
skin and connective tissue diseases
Pathogen
Pathological
Rheumatoid arthriti
Periodontal Diseases
Aged
Autoantibodies
Pharmacology
chemistry.chemical_classification
anti-c_vclic cirmllinaled peptide antibodie
biology
Peptidylarginine deiminase
business.industry
Middle Aged
medicine.disease
chemistry
Rheumatoid arthritis
biology.protein
Female
Periodontal disease
Antibody
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....878d9521838037dcfe9136b846751054