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Molecular networks in Network Medicine: Development and applications
- Source :
- Wiley Interdisciplinary Reviews-Systems Biology and Medicine, r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau), Wiley Interdiscip Rev Syst Biol Med, Silverman, E K, Schmidt, H H H W, Anastasiadou, E, Altucci, L, Angelini, M, Badimon, L, Balligand, J L, Benincasa, G, Capasso, G, Conte, F, Di Costanzo, A, Farina, L, Fiscon, G, Gatto, L, Gentili, M, Loscalzo, J, Marchese, C, Napoli, C, Paci, P, Petti, M, Quackenbush, J, Tieri, P, Viggiano, D, Vilahur, G, Glass, K & Baumbach, J 2020, ' Molecular networks in Network Medicine : Development and applications ', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 12, no. 6, e1489 . https://doi.org/10.1002/wsbm.1489, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Wiley interdisciplinary reviews. Systems biology and medicine, Vol. 12, no. 6, p. e1489 (2020), Wiley interdisciplinary reviews. Systems biology and medicine, (2020). doi:10.1002/wsbm.1489, info:cnr-pdr/source/autori:Silverman E.K.; Schmidt H.H.H.W.; Anastasiadou E.; Altucci L.; Angelini M.; Badimon L.; Balligand J.-L.; Benincasa G.; Capasso G.; Conte F.; Di Costanzo A.; Farina L.; Fiscon G.; Gatto L.; Gentili M.; Loscalzo J.; Marchese C.; Napoli C.; Paci P.; Petti M.; Quackenbush J.; Tieri P.; Viggiano D.; Vilahur G.; Glass K.; Baumbach J./titolo:Molecular networks in Network Medicine: Development and applications/doi:10.1002%2Fwsbm.1489/rivista:Wiley interdisciplinary reviews. Systems biology and medicine (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
- Publication Year :
- 2020
-
Abstract
- Network Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein–protein interaction networks, correlation‐based networks, gene regulatory networks, and Bayesian networks. Network Medicine applies these integrated approaches to Omics Big Data (including genetics, epigenetics, transcriptomics, metabolomics, and proteomics) using computational biology tools and, thereby, has the potential to provide improvements in the diagnosis, prognosis, and treatment of complex diseases. We discuss briefly the types of molecular data that are used in molecular network analyses, survey the analytical methods for inferring molecular networks, and review efforts to validate and visualize molecular networks. Successful applications of molecular network analysis have been reported in pulmonary arterial hypertension, coronary heart disease, diabetes mellitus, chronic lung diseases, and drug development. Important knowledge gaps in Network Medicine include incompleteness of the molecular interactome, challenges in ideNetwork Medicine applies network science approaches to investigate disease pathogenesis. Many different analytical methods have been used to infer relevant molecular networks, including protein–protein interaction networks, correlation‐based networks, gene regulatory networks, and Bayesian networks. Network Medicine applies these integrated approaches to Omics Big Data (including genetics, epigenetics, transcriptomics, metabolomics, and proteomics) using computational biology tools and, thereby, has the potential to provide improvements in the diagnosis, prognosis, and treatment of complex diseases. We discuss briefly the types of molecular data that are used in molecular network analyses, survey the analytical methods for inferring molecular networks, and review efforts to validate and visualize molecular networks. Successful applications of molecular network analysis have been reported in pulmonary arterial hypertension, coronary heart disease, diabetes mellitus, chronic lung diseases, and drug development. Important knowledge gaps in Network Medicine include incompleteness of the molecular interactome, challenges in identifying key genes within genetic association regions, and limited applications to human diseasesntifying key genes within genetic association regions, and limited applications to human diseases
- Subjects :
- Network medicine
Epigenomics
Computer science
EXPRESSION DATA
Big data
Gene regulatory network
big data
molecular networks
network medicine
Medicine (miscellaneous)
Network science
Coronary Disease
Computational biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Interactome
Article
03 medical and health sciences
0302 clinical medicine
INTEGRATED ANALYSIS
HUMAN GENOME
Animals
Humans
Gene Regulatory Networks
Protein Interaction Maps
EPIGENETIC REGULATION
030304 developmental biology
CELL-CULTURE
0303 health sciences
business.industry
COMPUTATIONAL AND SYSTEMS BIOLOGY
Translational medicine
Bayesian network
Computational Biology
Bayes Theorem
molecular network
STEM-CELL
3. Good health
Systems medicine
Disease Models, Animal
SYSTEMS BIOLOGY
VISUALIZATION
PROTEIN-INTERACTION NETWORKS
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 19395094
- Database :
- OpenAIRE
- Journal :
- Wiley Interdisciplinary Reviews-Systems Biology and Medicine, r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau), Wiley Interdiscip Rev Syst Biol Med, Silverman, E K, Schmidt, H H H W, Anastasiadou, E, Altucci, L, Angelini, M, Badimon, L, Balligand, J L, Benincasa, G, Capasso, G, Conte, F, Di Costanzo, A, Farina, L, Fiscon, G, Gatto, L, Gentili, M, Loscalzo, J, Marchese, C, Napoli, C, Paci, P, Petti, M, Quackenbush, J, Tieri, P, Viggiano, D, Vilahur, G, Glass, K & Baumbach, J 2020, ' Molecular networks in Network Medicine : Development and applications ', Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 12, no. 6, e1489 . https://doi.org/10.1002/wsbm.1489, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, Wiley interdisciplinary reviews. Systems biology and medicine, Vol. 12, no. 6, p. e1489 (2020), Wiley interdisciplinary reviews. Systems biology and medicine, (2020). doi:10.1002/wsbm.1489, info:cnr-pdr/source/autori:Silverman E.K.; Schmidt H.H.H.W.; Anastasiadou E.; Altucci L.; Angelini M.; Badimon L.; Balligand J.-L.; Benincasa G.; Capasso G.; Conte F.; Di Costanzo A.; Farina L.; Fiscon G.; Gatto L.; Gentili M.; Loscalzo J.; Marchese C.; Napoli C.; Paci P.; Petti M.; Quackenbush J.; Tieri P.; Viggiano D.; Vilahur G.; Glass K.; Baumbach J./titolo:Molecular networks in Network Medicine: Development and applications/doi:10.1002%2Fwsbm.1489/rivista:Wiley interdisciplinary reviews. Systems biology and medicine (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
- Accession number :
- edsair.doi.dedup.....8795e2d2ac9c4361169d5d50ba00f33a
- Full Text :
- https://doi.org/10.1002/wsbm.1489