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Interferon lambda 1 is associated with dengue severity in Thailand
- Source :
- International Journal of Infectious Diseases, Vol 93, Iss, Pp 121-125 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS). This study was performed to determine the host genetic factors responsible for dengue severity. Two single nucleotide polymorphisms (SNPs) of the interferon lambda 1 (IFNL1) gene (rs30461 and rs7247086) were analyzed for their association with dengue severity in a Thai population. Methods: This was a case–control association study involving 877 patients under the age of 15 years (DF, n = 386; DHF, n = 416; DSS, n = 75). Genotyping was performed by TaqMan real-time PCR assay. Results: It was found that the rs7247086 variant of IFNL1 was associated with DHF, but not DSS. Genotypes CT and TT and the T allele were protective against DHF (p = 0.03, odds ratio 0.62 for CT, odds ratio 0.13 for TT; and p = 0.01, odds ratio 0.54 for the T allele). The other SNP tested was not associated with DHF or DSS. Conclusions: The rs7247086 variant of IFNL1 (the T allele) was found to be protective against DHF, suggesting that IFNL1 may play a role in the pathogenesis of DHF. Keywords: Dengue, IFNL1, Genetic association, Disease severity
- Subjects :
- Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Genotype
Genotyping Techniques
030106 microbiology
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Gastroenterology
Dengue fever
lcsh:Infectious and parasitic diseases
Dengue
03 medical and health sciences
0302 clinical medicine
Internal medicine
Odds Ratio
Humans
Medicine
SNP
lcsh:RC109-216
030212 general & internal medicine
Allele
Child
Genotyping
Alleles
Genetic Association Studies
Genetic association
business.industry
Interleukins
virus diseases
General Medicine
Odds ratio
Thailand
medicine.disease
Infectious Diseases
Case-Control Studies
Female
Interferons
business
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....87aabf7a536597c3af315d0ed9872181