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Gene therapy returns to centre stage
- Source :
- Nature. 526:351-360
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Recent clinical trials of gene therapy have shown remarkable therapeutic benefits and an excellent safety record. They provide evidence for the long-sought promise of gene therapy to deliver 'cures' for some otherwise terminal or severely disabling conditions. Behind these advances lie improved vector designs that enable the safe delivery of therapeutic genes to specific cells. Technologies for editing genes and correcting inherited mutations, the engagement of stem cells to regenerate tissues and the effective exploitation of powerful immune responses to fight cancer are also contributing to the revitalization of gene therapy.
- Subjects :
- Clinical Trials as Topic
Multidisciplinary
business.industry
T-Lymphocytes
Genetic enhancement
medicine.medical_treatment
Gene targeting
Cancer
Genetic Therapy
Immunotherapy
Hematopoietic Stem Cells
Bioinformatics
medicine.disease
Clinical trial
Immune system
Liver
Organ Specificity
Neoplasms
Gene Targeting
medicine
Humans
Stem cell
business
Gene
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 526
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....87ae0778e879c04cf9a037d66d120ae7