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Reclassification of neuroendocrine tumors improves the separation of carcinoids and the prediction of survival
- Source :
- Journal of Thoracic Oncology, Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2008, 3 (12), pp.1410-5. ⟨10.1097/JTO.0b013e31818e0dd4⟩
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; INTRODUCTION: The classification of neuroendocrine lung tumors has changed over the last decades. Reliable diagnoses are crucial for the quality of clinical databases. The purpose of this study is to determine to which extent the use of different diagnostic criteria of neuroendocrine lung tumors has influenced the classification of these tumors. The prognostic information of tumor, node, metastasis descriptors was also evaluated. METHODS: We retrieved 110 tumors from the period 1989 to 2007. All tumors were reclassified according to the World Health Organization classification of 2004. Tumor, node, metastasis descriptors were evaluated. RESULTS: By reclassification, the diagnoses on 48 tumors (44%) were changed. More diagnoses were changed in the older part of the material. A significantly different survival was shown for all patients in relation to tumor size (p < 0.0001). An endobronchial component was seen in 54%, 31%, and 11% of typical carcinoid, atypical carcinoid, and large cell neuroendocrine carcinoma, respectively with no impact on survival (p = 0.90). For all included patients the survival was significantly worse for patients having metastasis to N1 nodes as compared with N0 (p = 0.03). However, the number of removed lymph nodes were insufficient for definitive determination of the prognostic impact of node metastases. Regarding the revised diagnoses, a significant difference in survival between typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma and small cell carcinoma was noted (p < 0.005). CONCLUSION: Tumors must be rediagnosed before entering a central database. Tumor and node seem to be useful predictors of survival.
- Subjects :
- Oncology
Male
Lung Neoplasms
Survival
MESH: Carcinoid Tumor
MESH: Lymphatic Metastasis
MESH: Lymph Nodes
Neuroendocrine tumors
TNM
Metastasis
MESH: Aged, 80 and over
Size
Carcinoma, Non-Small-Cell Lung
Medical diagnosis
Young adult
MESH: Bronchial Neoplasms
Aged, 80 and over
MESH: Aged
MESH: Middle Aged
Bronchial Neoplasms
Middle Aged
Classification
Prognosis
Survival Rate
MESH: Young Adult
Lymphatic Metastasis
MESH: Carcinoma, Large Cell
Female
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Adolescent
MESH: Survival Rate
[SDV.CAN]Life Sciences [q-bio]/Cancer
Carcinoid Tumor
Adenocarcinoma
MESH: Prognosis
Young Adult
Text mining
[SDV.CAN] Life Sciences [q-bio]/Cancer
Neuroendocrine tumor
Internal medicine
medicine
Carcinoma
Humans
Survival rate
Aged
Retrospective Studies
MESH: Adolescent
MESH: Humans
business.industry
MESH: Adenocarcinoma
Retrospective cohort study
MESH: Retrospective Studies
MESH: Adult
medicine.disease
MESH: Male
MESH: Lung Neoplasms
Endobronchial
Carcinoma, Large Cell
Lymph Nodes
business
MESH: Female
MESH: Carcinoma, Non-Small-Cell Lung
Subjects
Details
- Language :
- English
- ISSN :
- 15560864 and 15561380
- Database :
- OpenAIRE
- Journal :
- Journal of Thoracic Oncology, Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2008, 3 (12), pp.1410-5. ⟨10.1097/JTO.0b013e31818e0dd4⟩
- Accession number :
- edsair.doi.dedup.....87b21241af11484e35c40d106f7140b9