Isolable Pyridinium Trifluoromethoxide Salt for Nucleophilic Trifluoromethoxylation

Authors :: Jeff W. Kampf
Melanie S. Sanford
Douglas C. Bland
Geraldo Duran-Camacho
Devin M. Ferguson
Source :: Organic letters. 23(13)
Publication Year :: 2021
Abstract: An isolable pyridinium trifluoromethoxide salt is prepared from the reaction of 4-dimethylaminopyridine with the commercially available liquid 2,4-dinitro(trifluoromethoxy)benzene. The salt is an effective trifluoromethoxide source for SN2 reactions to form trifluoromethyl ethers.

Subjects :: chemistry.chemical_classification
Trifluoromethyl
010405 organic chemistry
Organic Chemistry
Salt (chemistry)
010402 general chemistry
01 natural sciences
Biochemistry
Medicinal chemistry
0104 chemical sciences
chemistry.chemical_compound
chemistry
Nucleophile
SN2 reaction
Pyridinium
Physical and Theoretical Chemistry
Benzene

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