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Gentisyl Alcohol Derivatives from the Marine-Derived Fungus Penicillium terrestre
- Source :
- Journal of Natural Products. 71:66-70
- Publication Year :
- 2007
- Publisher :
- American Chemical Society (ACS), 2007.
-
Abstract
- Nine new gentisyl alcohol derivatives, namely, the trimeric terrestrol A (8), dimeric terrestrols B-H (1-7), and a monomeric derivative (12), together with four known analogues (9-11, 13) were isolated from the marine-derived fungus Penicillium terrestre. The structures of the new compounds were elucidated by spectroscopic methods including one- and two-dimensional NMR as well as low- and high-resolution mass spectrometric analysis. These new compounds (1-8, 12) showed cytotoxic effects on HL-60, MOLT-4, BEL-7402, and A-549 cell lines with IC50 values in the range 5-65 microM. Compound 6 also showed moderate inhibitory activity against protein tyrosine kinases (Src and KDR). Furthermore, all new compounds exhibited moderate radical scavenging activity against DPPH with IC50 values in the range 2.6-8.5 microM.
- Subjects :
- China
Antioxidant
Stereochemistry
DPPH
medicine.medical_treatment
Dimer
Pharmaceutical Science
Antineoplastic Agents
Marine Biology
Trimer
Ether
Analytical Chemistry
Inhibitory Concentration 50
chemistry.chemical_compound
Picrates
Drug Discovery
medicine
Humans
Phenols
Benzyl Alcohols
Pharmacology
chemistry.chemical_classification
Molecular Structure
Biphenyl Compounds
Organic Chemistry
Penicillium
Biological activity
Free Radical Scavengers
Vascular Endothelial Growth Factor Receptor-2
src-Family Kinases
Enzyme
Complementary and alternative medicine
chemistry
Molecular Medicine
Drug Screening Assays, Antitumor
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....87bcc5de49aa21485e18308494d078a4