Back to Search
Start Over
Fermented pomegranate wastes as sustainable source of ellagic acid: Antioxidant properties, anti-inflammatory action, and controlled release under simulated digestion conditions
- Source :
- Food Chemistry. 246:129-136
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Wastes deriving from production of wines by yeast fermentation of Punica granatum (fermented pomegranate wastes, FPW) showed a marked antioxidant activity in a series of conventional chemical tests. HPLC/MS analysis of the methanol extract showed the presence of ellagic acid (EA) as the main phenolic component at levels up to 40% on a w/w basis. Experiments using murine macrophages showed that FPW extract is able to reduce the LPS-induced expression of pro-inflammatory genes IL-1β, TNF-α and iNOS. A remarkable increase in the antioxidant properties and extractable EA content was observed following acid hydrolytic treatment of FPW. Under simulated gastrointestinal conditions, EA was slowly released from FPW up to 80% of the overall content over 2 h incubation at the slightly alkaline pHs simulating the small intestine environment, suggesting a potential of the material in nutraceuticals and other applications.
- Subjects :
- Lipopolysaccharides
Magnetic Resonance Spectroscopy
Antioxidant
medicine.drug_class
medicine.medical_treatment
Wine
01 natural sciences
Antioxidants
Anti-inflammatory
Analytical Chemistry
Mice
chemistry.chemical_compound
Hydrolysis
0404 agricultural biotechnology
Ellagic Acid
Phenols
Acid hydrolysis, Anti-inflammatory, Antioxidant, Ellagic acid, Punica granatum L., Simulated gastrointestinal digestion, Wastes, Yeast fermentation
medicine
Animals
Food science
Inflammation
Lythraceae
Waste Products
biology
Plant Extracts
Anti-Inflammatory Agents, Non-Steroidal
010401 analytical chemistry
04 agricultural and veterinary sciences
General Medicine
biology.organism_classification
040401 food science
0104 chemical sciences
RAW 264.7 Cells
chemistry
Biochemistry
Delayed-Action Preparations
Punica
Fermentation
Digestion
Acid hydrolysis
Food Science
Ellagic acid
Subjects
Details
- ISSN :
- 03088146
- Volume :
- 246
- Database :
- OpenAIRE
- Journal :
- Food Chemistry
- Accession number :
- edsair.doi.dedup.....87c20d1276155391bbc1d345341a71b0