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MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls
- Source :
- European Archives of Psychiatry and Clinical Neuroscience. 263:393-403
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- MAOA and, to a lesser extent, MAOB poly- morphisms have been related to aggression traits and suicidality. We aimed to investigate the role of MAOA and MAOB in suicidal versus non-suicidal participants and interactions between genetic variation and suicidal status on aggression and anger-related traits. The sample was com- posed of three groups: one group of suicide attempters (n = 171, males 35.1 %), one group of suicide completers (n = 90, males 57.8 %) and a healthy control group (n = 317, males 43.8 %). We examined the following markers: MAOA rs909525, rs6323, and rs2064070, and MAOB rs1799836. Anger traits were measured with the state-trait anger expression inventory (STAXI) and aggression traits with the questionnaire for measuring fac- tors of aggression (FAF). Associations were separately examined for males and females. Variation in the three MAOA variants was associated with higher levels of anger expressed outwards (STAXI ''anger-out'' subscale) in male suicidal patients compared to controls (p \ 0.001). In females, the C allele of rs6323 showed higher scores on the same subscale (''anger out'') (p = 0.002). Allele frequen- cies of the MAOA rs909525 were associated with suici- dality (p \ 0.007). Our findings show an association between genetic variation in three polymorphisms of the MAOA and anger traits in suicidal males and one replication for the functional variant rs6323 in females. This relation- ship was stronger than a direct genetic association with suicide status. Future studies incorporating endophenotypic measures of anger and aggression in suicidal participants are warranted.
- Subjects :
- Adult
Male
medicine.medical_specialty
media_common.quotation_subject
DNA Mutational Analysis
MAO genes
Poison control
Anger
Polymorphism, Single Nucleotide
Suicide prevention
Sex Factors
Surveys and Questionnaires
Genetic variation
medicine
Humans
Pharmacology (medical)
Suicide, Anger, Aggression, MAO, genes
Allele
Psychiatry
Monoamine Oxidase
Biological Psychiatry
Aged
Genetic association
media_common
Analysis of Variance
Aggression
General Medicine
Middle Aged
Suicide
Psychiatry and Mental health
Female
Monoamine oxidase B
medicine.symptom
Psychology
Clinical psychology
Subjects
Details
- ISSN :
- 14338491 and 09401334
- Volume :
- 263
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....87c2ae840d584d3a23ac6a99e1eb2342