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Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
- Source :
- Molecular Psychiatry. 4:290-296
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic or environmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dopamine D2 receptor density in vivo, as measured by positron emission tomography and [11C]raclopride in 56 healthy subjects. There was a significant association between presence of a putative functional DRD2 promoter allele (-141C Del) and high striatal dopamine receptor density (t= 2.32, P= 0.02). In agreement with some previous studies the presence of the DRD2 TaqIA1 allele was associated with measures of low dopamine receptor density (t=2.58, P=0.01). Also the DRD2 TaqIB1 allele was associated with low dopamine receptor density (t= 2.58, P= 0.01) wheras there was no significant relationship between another common silent intronic DRD2 short tandem repeat polymorphism (STRP) and striatal dopamine D2 receptor density. The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects. The results should be interpreted with caution because of the limited sample size.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Biology
Linkage Disequilibrium
Receptors, Dopamine
Cellular and Molecular Neuroscience
Dopamine receptor D1
Reference Values
Internal medicine
Dopamine receptor D2
Salicylamides
Dopamine receptor D5
medicine
Humans
Carbon Radioisotopes
Allele
Promoter Regions, Genetic
Receptor
Molecular Biology
Alleles
Aged
Aged, 80 and over
Raclopride
Sex Characteristics
ANKK1
Polymorphism, Genetic
Receptors, Dopamine D2
Middle Aged
Corpus Striatum
Introns
Psychiatry and Mental health
Endocrinology
Dopamine receptor
Dopamine Antagonists
Female
Tomography, Emission-Computed
medicine.drug
Subjects
Details
- ISSN :
- 14765578 and 13594184
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecular Psychiatry
- Accession number :
- edsair.doi.dedup.....8806d255a0326739c79bd5d80bd35ed5
- Full Text :
- https://doi.org/10.1038/sj.mp.4000532