Back to Search
Start Over
Necator americanus: Optimization of the golden hamster model for testing anthelmintic drugs
- Source :
- Experimental Parasitology. 111:219-223
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Laboratory golden hamsters (Mesocricetus auratus) were infected with Necator americanus under several different parasite and host conditions to optimize the model for testing anthelminthic drugs. The results confirmed that male hamsters were more susceptible to infection than females. Host age in the range of 5-15 weeks was not a factor that impacted on adult worm burden, and similar worm burdens were achieved using doses of 150, 250 or 500 N. americanus L3 (NaL3). The largest numbers of adult hookworms were recovered on days 21-28 post-infection, with a significant decrease at days 40-50 post-infection. Therefore adult worm recovery is maximal approximately 11-18 days prior to patency and host blood loss. From these studies a drug evaluation protocol was developed using 150 NaL3 as the infectious dose and then evaluating the anthelminthic effects of the drugs albendazole, tribendimidine, and pyrantel pamoate on days 21-28 post-infection. The model confirms the anthelminthic activity of albendazole, tribendimidine, and pyrantel pamoate and has the potential as a laboratory animal model to detect emerging drug resistance.
- Subjects :
- Male
Veterinary medicine
Necator americanus
Immunology
Pyrantel Pamoate
Physiology
Phenylenediamines
Biology
Albendazole
Tribendimidine
Necatoriasis
Deworming
Sex Factors
Cricetinae
parasitic diseases
medicine
Animals
Anthelmintic
Anthelmintics
Mesocricetus
Infectious dose
Age Factors
General Medicine
biology.organism_classification
Disease Models, Animal
Infectious Diseases
Erythrocyte Count
Female
Parasitology
medicine.drug
Subjects
Details
- ISSN :
- 00144894
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Experimental Parasitology
- Accession number :
- edsair.doi.dedup.....8809e4a3fdd28164b905a0468f7f1238