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Evidence of Overlapping Genetic Diathesis of Panic Attacks and Gastrointestinal Disorders in a Sample of Male Twin Pairs
- Source :
- Twin Research and Human Genetics. 14:16-24
- Publication Year :
- 2011
- Publisher :
- Cambridge University Press (CUP), 2011.
-
Abstract
- We explored the comorbidity between panic attacks (PA), whose symptoms can include gastrointestinal discomfort, and gastrointestinal disorders (GD). Structural equation modeling was used to analyze data from 1,874 MZ and 1,498 DZ male–male twin pairs from the Vietnam Era Twin Registry. PA and GD were associated (relative risk for GD = 2). The percentage of liability due to genetic factors was estimated to be 37% for PA and 31% for GD. There was significant correlation between the genetic risk factors for PA and GD (estimated r = .55, 95% CI of 34% to 82%) and no evidence of correlation between the environmental causes of PA and GD. Therefore, PA and GD comorbidity can be explained by overlapping genetic factors and not overlapping environmental factors. Although these data cannot identify a biological pathway for such a shared liability, it suggests the presence of GD may be informative for genetic studies of panic.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Gastrointestinal Diseases
Comorbidity
Environment
Article
Correlation
Risk Factors
Internal medicine
Diseases in Twins
Twins, Dizygotic
medicine
Humans
Genetic Predisposition to Disease
Genetic risk
Psychiatry
Genetics (clinical)
Irritable bowel syndrome
Models, Genetic
business.industry
Panic disorder
Obstetrics and Gynecology
Panic
Diathesis
medicine.disease
Vietnam
Relative risk
Pediatrics, Perinatology and Child Health
Panic Disorder
medicine.symptom
business
Subjects
Details
- ISSN :
- 18392628 and 18324274
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Twin Research and Human Genetics
- Accession number :
- edsair.doi.dedup.....88165f58317de9f9536c99c117b9e2e5