Back to Search
Start Over
A coassembled peptide hydrogel boosts the radiosensitization of cisplatin
- Source :
- Chemical Communications. 56:13017-13020
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt-DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.
- Subjects :
- Radiation-Sensitizing Agents
Cell Survival
Supramolecular chemistry
Antineoplastic Agents
Peptide
macromolecular substances
complex mixtures
Catalysis
Adduct
Materials Chemistry
medicine
Humans
Cell Proliferation
A549 cell
Cisplatin
chemistry.chemical_classification
Cyclooxygenase 2 Inhibitors
Molecular Structure
Chemistry
technology, industry, and agriculture
Metals and Alloys
Hydrogels
Cell Cycle Checkpoints
General Chemistry
Cell cycle
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
A549 Cells
Cyclooxygenase 2
Ceramics and Composites
Biophysics
Drug Screening Assays, Antitumor
Peptides
medicine.drug
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....882000cced4e4af3cc2fe74e19b94402
- Full Text :
- https://doi.org/10.1039/d0cc05184e