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Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 5297, p 5297 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGKα, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA.
- Subjects :
- MAPK/ERK pathway
Diacylglycerol Kinase
RHOA
MAP Kinase Signaling System
RAC1
Review
Biology
Catalysis
Diglycerides
Inorganic Chemistry
lipids
lcsh:Chemistry
Cell Movement
Neoplasms
medicine
Animals
Humans
cancer
DGK
Physical and Theoretical Chemistry
Molecular Biology
Protein kinase B
lcsh:QH301-705.5
Spectroscopy
PI3K/AKT/mTOR pathway
Diacylglycerol kinase
diacylglycerol
Kinase
DGKs
Organic Chemistry
Cancer
General Medicine
Lipid
medicine.disease
Neoplasm Proteins
Computer Science Applications
Cell biology
phosphoinositide
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
PI3K/Akt/mTOR
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 5297
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....88423d4b9a5ef0318c41e0871e25a1ec