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Genetic association analyses highlight IL6, ALPL, and NAV1 as three new susceptibility genes underlying calcific aortic valve stenosis
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- To date, only two replicated loci, LPA and PALMD, have been identified as causal genes for calcific aortic valve stenosis (CAVS) using genome-wide and transcriptome-wide association study (TWAS). To identify additional susceptibility genes for CAVS, we performed a GWAS meta-analysis totaling 5,115 cases and 354,072 controls of European descent. Four loci achieved genome-wide significance, including two new loci: IL6 (interleukin 6) on 7p15.3 and ALPL (alkaline phosphatase) on 1p36.12. A TWAS integrating an eQTL study of 233 human aortic valves identified NAV1 (neuron navigator 1) on 1q32.1 as a new candidate causal gene. The CAVS risk alleles were associated with higher mRNA expression of NAV1 in valve tissues. Association results at the genome-wide scale showed genetic correlation with coronary artery disease and cardiovascular risk factors. Our study highlights three new loci implicating inflammation, mineralization and blood vessel integrity in CAVS pathogenesis and supports shared genetic etiology with cardiovascular traits.
- Subjects :
- Genetics
0303 health sciences
ALPL
Calcific aortic valve stenosis
Genome-wide association study
030204 cardiovascular system & hematology
Biology
medicine.disease
3. Good health
Coronary artery disease
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Expression quantitative trait loci
cardiovascular system
medicine
Gene
030304 developmental biology
Genetic association
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....884421bc03bad38ebdf491779fc10dfb