Hydrolytic Stability of Hydroxyphenyl Boronic Acids(HPBAs) and Employment of Poly(HPBAs) for Voltammetric Determination of Fluoride Levels in Dental Formulations and Beverages; Significance of Raw DPV Data for Chemometric Discrimination

Physicochemical and electrochemical properties of hydroxyphenyl boronic acids(HPBAs) and their use in fluoride determinations were investigated. HPBAs were electropolymerized at pH 1.0-11.0 in 40-60 %(v/v) methanol-buffer. Differential pulse voltammetry(DPV) determinations of fluoride (with 1.0x10(-5)-1.0x10(-4) M linearity based on potential shift) using poly(HPBAs) glassy carbon electrodes(GCEs) have -45.49 to +34.40 % error range. Significance of raw DPV data for chemometric discrimination was investigated by principle component analysis. This is the first demonstration of fluoride determination with poly(HPBAs)GCEs and chemometric discrimination of pharmaceutical formulations so far. Due to the lack of experimental data in literature, current findings will make a contribution to literature.
National Boron Research Institute (BOREN) [BOREN2008-C0138]; University of Ege Department of Scientific Research Projects (BAP) [2008-BIL-002]
This study was supported by a grant from National Boron Research Institute (BOREN, Project number: BOREN2008-C0138) and a grant from University of Ege Department of Scientific Research Projects (BAP, Project number: 2008-BIL-002). The authors would also like to thank FABAL (Pharmaceutical Sciences Research Laboratory of Faculty of Pharmacy of University of Ege, Izmir, Turkiye -https://www.fabal.ege.edu.tr) where DSC, TGA and FTIR measurements were performed.