Back to Search
Start Over
Effect of Whey Protein Supplementation on Inflammatory and Antioxidant Markers, and Clinical Prognosis in Acute Ischemic Stroke (TNS Trial): A Randomized, Double Blind, Controlled, Clinical Trial
- Source :
- Advanced Pharmaceutical Bulletin, Advanced Pharmaceutical Bulletin, Vol 10, Iss 1, Pp 135-140 (2020)
- Publication Year :
- 2019
- Publisher :
- Tabriz University of Medical Sciences, 2019.
-
Abstract
- Purpose: Malnutrition is extensively prevalent amongst critically ill patients afflicted by ischemic stroke (IS). This study purpose was to evaluate the protein whey effect on inflammatory and antioxidant markers and functional prognosis in acute IS patients. Methods: out of 42 patients with acute IS who were referred to Imam Reza Educational Hospital, Tabriz, Iran, 40 patients participated in the study. Twenty-one patients as control group received the hospital routine formula, and 19 patients as intervention group received 20 g/daily of whey protein through oral gavage. Inflammation and oxidative stress indicators (e.g., albumin, malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and high sensitivity C reactive protein (hs-CRP)and clinical variables included in were evaluated using National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) during admission and also 3 weeks after intervention. Results: Whey protein supplementation significantly decreased the NIHSS and mRS scores, TNF-α, IL-6, and hs-CRP by passing 3 weeks from intervention (P
- Subjects :
- Whey protein
medicine.medical_specialty
030309 nutrition & dietetics
Pharmaceutical Science
Gastroenterology
Brain ischemia
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Modified Rankin Scale
Internal medicine
medicine
General Pharmacology, Toxicology and Pharmaceutics
Stroke
Inflammation
0303 health sciences
biology
business.industry
C-reactive protein
lcsh:RM1-950
Malnutrition
Albumin
Malondialdehyde
medicine.disease
Clinical trial
lcsh:Therapeutics. Pharmacology
chemistry
Oxidative stress
biology.protein
business
030217 neurology & neurosurgery
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 22517308 and 22285881
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Advanced Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....88658393af8ce84f8b5cb7f396eb43cb