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DrosophilaRegulatory factor X is necessary for ciliated sensory neuron differentiation
- Source :
- Development, Development, Palgrave Macmillan, 2002, 129 (23), pp.5487-5498. ⟨10.1242/dev.00148⟩, Development, 2002, 129 (23), pp.5487-5498. ⟨10.1242/dev.00148⟩
- Publication Year :
- 2002
- Publisher :
- The Company of Biologists, 2002.
-
Abstract
- International audience; Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfx mutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila.
- Subjects :
- Male
[SDV]Life Sciences [q-bio]
Genes, Insect
MESH: Genes, Insect
0302 clinical medicine
Morphogenesis
Drosophila Proteins
MESH: Animals
RFX
media_common
0303 health sciences
MESH: Electrophysiology
MESH: Neurons, Afferent
Cilium
Ciliated sensory neuron
Cell Differentiation
MESH: Transcription Factors
MESH: Regulatory Factor X Transcription Factors
Cell biology
DNA-Binding Proteins
Electrophysiology
Drosophila melanogaster
Phenotype
medicine.anatomical_structure
Drosophila
Female
Transduction (physiology)
MESH: Cell Differentiation
MESH: Mutation
MESH: Drosophila Proteins
Recombinant Fusion Proteins
media_common.quotation_subject
Molecular Sequence Data
Regulatory Factor-X
Regulatory Factor X Transcription Factors
Sensory system
Biology
MESH: Phenotype
MESH: Drosophila melanogaster
03 medical and health sciences
MESH: Cilia
Perception
medicine
Animals
Humans
Amino Acid Sequence
Cilia
Neurons, Afferent
Molecular Biology
030304 developmental biology
MESH: Molecular Sequence Data
MESH: Morphogenesis
Sensory neuron
Mutation
MESH: Female
Sequence Alignment
Developmental biology
MESH: DNA-Binding Proteins
030217 neurology & neurosurgery
Transcription Factors
Developmental Biology
Subjects
Details
- ISSN :
- 14779129, 09501991, and 10116370
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....886e67cb02d2db55d508ad17697ae54e