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Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
- Source :
- Toxins, Vol 11, Iss 6, p 355 (2019), Toxins, vol 11, iss 6
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5–40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action.
- Subjects :
- Proteases
Insecticides
Serine Proteinase Inhibitors
Health, Toxicology and Mutagenesis
Anti-Inflammatory Agents
Spider Venoms
venom
lcsh:Medicine
Context (language use)
Venom
Antineoplastic Agents
Biology
Toxicology
complex mixtures
biotools
03 medical and health sciences
Translationally-controlled tumor protein
drug targets
Animals
Humans
Translationally-Controlled 1
Envenomation
030304 developmental biology
0303 health sciences
Analgesics
Phosphoric Diester Hydrolases
novel therapeutics
030302 biochemistry & molecular biology
lcsh:R
toxins
Pharmacology and Pharmaceutical Sciences
brown spider
Recombinant Proteins
Brown spider
Neuroprotective Agents
Biochemistry
Snake venom
Tumor Protein
Inhibitor cystine knot
Immunotherapy
Biochemistry and Cell Biology
Peptides
Loxosceles
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Volume :
- 11
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....8872e6fcd99752166cb50bbcccbced55