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Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function
- Source :
- Acta pharmacologica Sinica. 34(12)
- Publication Year :
- 2013
-
Abstract
- Baroreflex dysfunction is associated with a higher rate of sudden death after myocardial infarction (MI). Ketanserin enhances baroreflex function in rats. The present work was designed to examine whether ketanserin improves the post-MI cardiac function and to explore the possible mechanism involved. Spontaneously hypertensive rats (SHR) were treated with ketanserin (0.3 mg·kg−1·d−1). Two weeks later, blood pressure and baroreflex function were measured, followed by a ligation of the left coronary artery. The expressions of vesicular acetylcholine transporter (VAChT) and α7 nicotinic acetylcholine receptor (α7-nAChR) in ischemic myocardium, angiogenesis, cardiac function, and left ventricular (LV) remodeling were evaluated subsequently. Ketanserin significantly improved baroreflex sensitivity (0.62±0.21 vs 0.34±0.12 ms/mmHg, P
- Subjects :
- Cardiac function curve
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Ketanserin
Myocardial Infarction
Enzyme-Linked Immunosorbent Assay
Baroreflex
Sudden death
Internal medicine
Rats, Inbred SHR
Heart rate
medicine
Animals
Pharmacology (medical)
cardiovascular diseases
Myocardial infarction
Pharmacology
Ejection fraction
business.industry
musculoskeletal, neural, and ocular physiology
Heart
General Medicine
medicine.disease
Acetylcholine
Rats
Blood pressure
Endocrinology
cardiovascular system
Original Article
business
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 17457254
- Volume :
- 34
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Acta pharmacologica Sinica
- Accession number :
- edsair.doi.dedup.....8875c68d85eda4b9d438e2bc92c0a686