Back to Search
Start Over
Chromosome 1q21 abnormalities in multiple myeloma
- Source :
- Blood Cancer Journal, Vol 11, Iss 4, Pp 1-11 (2021), Blood Cancer Journal
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group, 2021.
-
Abstract
- Gain of chromosome 1q (+1q) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly diagnosed cases. Although it is often considered a poor prognostic marker in MM, +1q has not been uniformly adopted as a high-risk cytogenetic abnormality in guidelines. Controversy exists regarding the importance of copy number, as well as whether +1q is itself a driver of poor outcomes or merely a common passenger genetic abnormality in biologically unstable disease. Although the identification of a clear pathogenic mechanism from +1q remains elusive, many genes at the 1q21 locus have been proposed to cause early progression and resistance to anti-myeloma therapy. The plethora of potential drivers suggests that +1q is not only a causative factor or poor outcomes in MM but may be targetable and/or predictive of response to novel therapies. This review will summarize our current understanding of the pathogenesis of +1q in plasma cell neoplasms, the impact of 1q copy number, identify potential genetic drivers of poor outcomes within this subset, and attempt to clarify its clinical significance and implications for the management of patients with multiple myeloma.
- Subjects :
- Gene Dosage
Myeloma
Locus (genetics)
Review Article
Disease
Bioinformatics
Pathogenesis
Cancer genomics
Animals
Humans
Medicine
Clinical significance
Multiple myeloma
RC254-282
Chromosome Aberrations
business.industry
Mechanism (biology)
Chromosome
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Hematology
Plasma cell neoplasm
medicine.disease
Oncology
Chromosomes, Human, Pair 1
Genetic Loci
Multiple Myeloma
business
Subjects
Details
- Language :
- English
- ISSN :
- 20445385
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Blood Cancer Journal
- Accession number :
- edsair.doi.dedup.....8876bd2b5977ed4b7aa3ce1e7b981aba