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Transcriptional derepression as a cause of genetic diseases
- Source :
- Current Opinion in Genetics & Development. 13:239-245
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms. Recently, inappropriate transcriptional derepression has been found as the underlying basis of several human genetic diseases. The putative target genes, whose inappropriate expression is thought to cause disease, have remained elusive but are being searched for intensively.
- Subjects :
- Beckwith-Wiedemann Syndrome
Transcription, Genetic
Biology
Mice
gene silencing
chemistry.chemical_compound
Transcription (biology)
Rett Syndrome
Genetics
Animals
Humans
Gene silencing
Epigenetics
Gene
Derepression
Regulation of gene expression
FSHD
Messenger RNA
epigenetics
transcriptional derepression
Genetic Diseases, Inborn
ICF
Myoclonic Epilepsies, Progressive
Gene Expression Regulation
chemistry
DNA
Developmental Biology
Subjects
Details
- ISSN :
- 0959437X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Genetics & Development
- Accession number :
- edsair.doi.dedup.....887acd68914fb7f844053ec2be90adaa